Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
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Summary
It is reported here that by acting on NMDA (N-methyl-D-aspartate) receptors on cerebellar cells, glutamate induces the release of a diffusible messenger with strikingly similar properties to EDRF that accounts for the cGMP responses that take place following NMDA receptor activation.
- Type
- article
- Published
- 1988-11-24
- Cited by
- 2,583
- References
- 21
- OpenAlex
- https://openalex.org/W2024862570
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4361381
Keywords
Second messenger system, Glutamate receptor, NMDA receptor, Acetylcholine, Postsynaptic potential
References
- L-Arginine identified as an endogenous activator for soluble guanylate cyclase from neuroblastoma cells.
- Role of calcium in endothelium-dependent relaxation of arterial smooth muscle.
- Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite.
- Endothelium‐Derived Relaxing Factor From Pulmonary Artery and Vein Possesses Pharmacologic and Chemical Properties Identical to Those of Nitric Oxide Radical
- Magnesium gates glutamate-activated channels in mouse central neurones
- Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
- NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
- Cyclic nucleotides in spinal cells.
- Vascular endothelial cells synthesize nitric oxide from L-arginine
- NMDA receptors - their role in long-term potentiation
- Species-dependent differences in the nature of endothelium-derived vascular relaxing factor.
- Purification and properties of guanylate cyclase from the synaptosomal soluble fraction of rat brain.
- Cellular uptake disguises action of L‐glutamate on N‐methyl‐D‐aspartate receptors: With an appendix: Diffusion of transported amino acids into brain slices
- Guanylate cyclase activities in enriched preparations of neurones, astroglia and a synaptic complex isolated from rat cerebellum.
- Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
- Excitatory amino acid receptors and guanosine 3',5'-cyclic monophosphate in incubated slices of immature and adult rat cerebellum.
- Modulation of vascular smooth muscle contraction by the endothelium.
- Cellular Origins of Cyclic GMP Responses to Excitatory Amino Acid Receptor Agonists in Rat Cerebellum In Vitro
- Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.
- The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Cited by
- Mechanisms of L-NG-nitro arginine methyl ester-induced antinociception in mice: a role for serotonergic and adrenergic neurons.
- Purification and characterization of a human NO synthase.
- Pathogenesis of migraine.
- The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G.
- Expression of the potent vasoconstrictor endothelin in the human central nervous system.
- Nitric oxide participates in the regulation of pancreatic acinar cell secretion.
- Nitric oxide synthase inhibitors prevent N-methyl-D-aspartic acid-induced penile erection and yawning in male rats.
- Angiotensin-(1-7) and nitric oxide synthase in the hypothalamo-neurohypophysial system.
- Release of nitric oxide evoked by nerve stimulation in guinea-pig intestine.
- NO at work
- Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade.
- The impaired long-term potentiation in the CA1 field of the hippocampus of cognitive deficient microencephalic rats is restored by D-serine.
- Activation of soluble guanylate cyclase through phosphorylation by protein kinase C in intact PC12 cells.
- Modulation of human T cell responses by nitric oxide and its derivative, S-nitrosoglutathione.
- Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-D-aspartate neurotoxicity.
- Cloned and expressed nitric oxide synthase proteins.
- Correlation between brain nitric oxide synthase activity and opiate withdrawal
- Age-related increase in nitric oxide synthase activity in senescence accelerated mouse brain and the effect of long-term administration of superoxide radical scavenger.
- Effect of nitric oxide synthase inhibition on cardiorespiratory responses in the conscious rat.
- Prenatal development of nicotinamide adenine dinucleotide phosphate‐diaphorase activity in the human hippocampal formation
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