Vascular endothelial cells synthesize nitric oxide from L-arginine
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Summary
It is demonstrated that NO can be synthesized from L-arginine by porcine aortic endothelial cells in culture and the strict substrate specificity of this reaction suggests that L- arginine is the precursor for NO synthesis in vascular endothelium cells.
- Type
- article
- Published
- 1988-06-16
- Cited by
- 4,982
- References
- 11
- OpenAlex
- https://openalex.org/W2048635427
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4329084
Keywords
Nitric oxide, Arginine, Citrulline, Chemistry, Bradykinin
References
- The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium.
- Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.
- Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
- Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells
- Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.
- Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
- Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
- The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide
- The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
- Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP.
Cited by
- Putative mechanisms for vascular damage by homocysteine
- Inhibition of chemotaxis Ng-monomethyl-L-arginine: a role for cyclic GMP.
- Role of nitric oxide in the autonomic innervation of smooth muscle.
- Novel synthesis of S-nitrosoglutathione and degradation by human neutrophils.
- Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition.
- [Aging and endothelial function].
- Modulation of neuroeffector transmission in the guinea pig pulmonary artery by endogenous nitric oxide.
- l-Arginine therapy in Raynaud's phenomenon?
- Pulmonary vasoconstriction induced by mitral valve obstruction in sheep.
- Anti-inflammatory Effects of the Aqueous Extract of Hwangnyeonhaedok-tang in LPS-activated Macrophage Cells
- Endothelial Dysfunction in Essential Hypertension
- Cytosolic calcium ion regulation in cultured endothelial cells.
- Modulating Mechanisms of Neuroendocrine Cell Activity: The LHRH Pulse Generator
- Nitric Oxide and Platelet-Mediated Hemostasis
- Ammonia and Manganese Increase Arginine Uptake in Cultured Astrocytes
- Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats.
- Nitric oxide participates in the regulation of pancreatic acinar cell secretion.
- Role of nitric oxide in prevention of ethanol-induced gastric damage by CuNSN a copper-chelating compound
- Pathobiology of intimal hyperplasia
- Discrimination between citrulline and arginine transport in activated murine macrophages: inefficient synthesis of NO from recycling of citrulline to arginine
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