NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
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Summary
It is directly demonstrated that excitatory amino acids acting at NMDA receptors on spinal cord neurones increase the intracellular Ca2+ activity, measured using the indicator dye arsenazo III, and that this is the result of Ca2- influx through NMDA receptor channels.
- Type
- article
- Published
- 1986-05-01
- Cited by
- 1,727
- References
- 27
- OpenAlex
- https://openalex.org/W2010926499
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4342645
Keywords
NMDA receptor, Excitatory postsynaptic potential, Chemistry, Biophysics, Kainic acid
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Cited by
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- Combined therapy with MK‐801 and nimodipine for protection of ischemic brain damage
- Elevation of intracellular calcium content in area CA1 of hippocampus is not directly correlated with the development of long-term potentiation.
- Giant synaptic potentials in immature rat CA3 hippocampal neurones.
- Binding of [3H]inositoltrisphosphate and [3H]phorbol 12,13-dibutyrate in rat hippocampus following transient global ischemia: a quantitative autoradiographic study.
- Localization of 70-kDa stress protein induction in gerbil brain after ischemia
- Noxious stimuli induce an N‐methyl‐D‐aspartate receptor‐dependent hypersensitivity of the flexion withdrawal reflex to touch: implications for the treatment of mechanical allodynia
- Primary cultures of neurons for testing neuroprotective drug effects.
- Transient ischemia causes a reduction of Mg2+ blockade of NMDA receptors.
- Steroid hormones protect spinal cord neurons from glutamate toxicity.
- Dendritic calcium channels and hippocampal long‐term depression
- Interneurons of the hippocampus
- Developmental Expression and Self‐regulation of Ca2+ Entry via AMPA/KA Receptors in the Embryonic Chick Retina
- Spatiotemporal distribution of intracellular calcium transients during epileptiform activity in guinea pig hippocampal slices.
- Toward the Development of Strategies to Prevent Ischemic Neuronal Injury
- Spinal calmodulin inhibitors reduce N-methyl-D-aspartate- and septide-induced nociceptive behavior.
- Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage
- Cyclic AMP Regulates the Expression of Neurokinin1 Receptors by Neonatal Rat Spinal Neurons in Culture
- Ischemia but not anoxia evokes vesicular and Ca(2+)-independent glutamate release in the dorsal vagal complex in vitro.
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