Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
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Summary
It is demonstrated that EDRF is protected from breakdown by superoxide dismutase (SOD) and Cu2+, but not by catalase, and is inactivated by Fe2+.
- Type
- article
- Published
- 1986-04-03
- Cited by
- 2,481
- References
- 17
- OpenAlex
- https://openalex.org/W2093518775
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4311116
Keywords
Superoxide, Endothelium-derived relaxing factor, Prostacyclin, Bradykinin, Chemistry
References
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- Superoxide and Superoxide Dismutases
- Effect of oxygen and endotoxin on lactate dehydrogenase release, 5‐hydroxytryptamine uptake, and antioxidant enzyme activities in endothelial cells
- The nature of endothelium-derived vascular relaxant factor
- The role of endothelium in the responses of vascular smooth muscle to drugs.
- Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.
- The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
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- Vascular renin-angiotensin-system, endothelial function and atherosclerosis?
- Co-purification of 130 kD nitric oxide synthase and a 22 kD link protein from human neutrophils.
- L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine.
- [Aging and endothelial function].
- Endothelial dysfunction in atherosclerosis.
- Release of endothelium‐derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester
- 死体肺移植における一酸化窒素吸入(NO)の有効性と至適投与時間についての実験的検討
- Endothelial Dysfunction in Essential Hypertension
- Rabbit Polymorphonuclear Neutrophils Elicit Endothelium-Dependent Contraction in Vascular Smooth Muscle
- Mediators and the anti-thrombotic properties of the vascular endothelium.
- The influence of calcium channel blockers on superoxide anions.
- Role of nitric oxide in prevention of ethanol-induced gastric damage by CuNSN a copper-chelating compound
- Pre-eclampsia: physiology and immunological aspects.
- Release of nitric oxide evoked by nerve stimulation in guinea-pig intestine.
- Free radicals in diabetic endothelial cell dysfunction.
- Biological Antioxidant Defenses
- Nω-nitro-L-arginine, an inhibitor of nitric oxide synthesis, decreases noradrenaline outflow in rat isolated perfused mesenteric vasculature
- Nitric oxide prevents neutrophil-mediated acute renal failure.
- Effects of Oxygen Radicals and Radical Scavenging on Opossum Lower Esophageal Sphincter
- Nitric oxide and pregnancy.
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