p63: A New Link Between Senescence and Aging
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Summary
The recent discovery that loss of the p53-related protein p63 induces cellular senescence and causes features of accelerated aging provides further evidence that cellularsenescence is intimately linked with organismal aging, and identifies p63 as a key regulator of both of these processes.
- Type
- dissertation
- Published
- 2006-01-13
- Cited by
- 49
- References
- 68
- Access
- Open access
- OpenAlex
- https://openalex.org/W16434880
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14990385
Keywords
Dream, Witness, Athletes, Scholarship, Dialectic
References
- Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
- p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
- PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
- Regulation of cellular senescence by p53.
- p63 is a p53 homologue required for limb and epidermal morphogenesis
- Regulation of the Cyclin-Dependent Kinase Inhibitor p57Kip2 Expression by p63
- DeltaNp63alpha up-regulates the Hsp70 gene in human cancer.
- DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development.
- DeltaNp63 induces beta-catenin nuclear accumulation and signaling.
- Transgenic Mouse Models Provide New Insights into the Role of p63 in Epidermal Development
- Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
- A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
- The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63
- Roles of p63 in Differentiation of Müllerian Duct Epithelial Cells
- β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
- p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
- p63 and the epithelial stem cell: more than status quo?
- Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
- p53 Homologue p63 Represses Epidermal Growth Factor Receptor Expression*
- The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells.
Cited by
- Tumor suppression by p53: making cells senescent
- Targeting Breast Cancer Recurrence via Hedgehog-Mediated Sensitization of Breast Cancer Stem Cells
- Biological Impact of Senescence Induction in Prostate Cancer Therapy
- Senescence Regulation by the p53 Protein Family
- Investigate correlation between mechanical property and aging biomarker in passaged human dermal fibroblasts
- Proliferation and Ability for Epidermal Autoregeneration in Patients with Chronic Lower Leg Venous Ulcerations
- p63 and p73: Life and Death in Squamous Cell Carcinoma
- Axis of ageing: telomeres, p53 and mitochondria
- p63: The Phantom of the Tumor Suppressor
- ΔNp63α promotes cellular quiescence via induction and activation of Notch3
- Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis.
- Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema.
- The alpha/beta carboxyterminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins
- Androgen Receptor Drives Cellular Senescence
- p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis
- Cell density‐dependent acetylation of ΔNp63α is associated with p53‐dependent cell cycle arrest
- Cellular senescence and organismal aging.
- Significance of cellular senescence in aging and cancer.
- p63, Cellular Senescence and Tumor Development
- Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging
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