Myeloid related proteins activate Toll-like receptor 4 in human acute coronary syndromes.
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Summary
This specific MRP8/14-dependent pathway with striking similarities to sepsis increasing expression of TLR4 in thrombi appears to be involved in the pathogenesis of coronary occlusion and may represent a novel therapeutic target in ACS.
- Type
- article
- Published
- 2011-10-01
- Cited by
- 50
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W2023651865
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40089889
Keywords
CD14, TLR4, TLR2, Monocyte, Receptor
References
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- Characterization of a human macrophage-like cell line stimulated in vitro: a model of macrophage functions.
- DAMPening Inflammation by Modulating TLR Signalling
- Toll-like receptor signal transduction
- The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells
- The S100 Family Heterodimer, MRP-8/14, Binds with High Affinity to Heparin and Heparan Sulfate Glycosaminoglycans on Endothelial Cells*
- Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis.
- Proinflammatory S100 proteins in arthritis and autoimmune disease.
- Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes.
- Atherosclerosis research from past to present—on the track of two pathologists with opposing views, Carl von Rokitansky and Rudolf Virchow
- S100 proteins expressed in phagocytes: a novel group of damage‐associated molecular pattern molecules
- Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial.
- A Heterocomplex Formed by the Calcium-binding Proteins MRP8 (S100A8) and MRP14 (S100A9) Binds Unsaturated Fatty Acids with High Affinity*
- Characterization of Monoclonal Antibody HTA125 with Specificity for Human TLR4
- Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction*
- Interaction of S100A8/S100A9-arachidonic acid complexes with the scavenger receptor CD36 may facilitate fatty acid uptake by endothelial cells.
- Removal of endotoxin from recombinant protein preparations.
- Therapeutics targeting the innate immune system
- Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor
Cited by
- Human monocyte subsets in coronary artery disease and myocardial infarction
- Targeting Inflammation: Impact on Atherothrombosis
- Biological variation of established and novel biomarkers for atherosclerosis: Results from a prospective, parallel-group cohort study.
- The Effect of miR-132, miR-146a, and miR-155 on MRP8/TLR4-Induced Astrocyte-Related Inflammation
- The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis.
- Coronary neutrophil extracellular trap burden and deoxyribonuclease activity in ST-elevation acute coronary syndrome are predictors of ST-segment resolution and infarct size.
- Physical Activity in the Management of Patients with Coronary Artery Disease: A Review
- Molecular characterization of peripheral arterial disease in proximal extremity arteries.
- Pathogenesis of acute coronary syndromes.
- Generic tools to assess genuine carbohydrate specific effects on in vitro immune modulation exemplified by β-glucans.
- Role of calprotectin in cardiometabolic diseases.
- Myoloid-Related Protein 8, an Endogenous Ligand of Toll-Like Receptor 4, Is Involved in Epileptogenesis of Mesial Temporal Lobe Epilepsy Via Activation of the Nuclear Factor-κB Pathway in Astrocytes
- Altered CD31 expression and activity in helper T cells of acute coronary syndrome patients
- S100A8 Contributes to Drug Resistance by Promoting Autophagy in Leukemia Cells
- Anti-Inflammatory Strategies for Plaque Stabilization after Acute Coronary Syndromes
- TLR4 expression on monocyte subsets in myocardial infarction
- Infections, immunity and atherosclerosis: pathogenic mechanisms and unsolved questions.
- High Levels of S100A12 Are Associated With Recent Plaque Symptomatology in Patients With Carotid Atherosclerosis
- S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease
- Advances in mechanisms, imaging and management of the unstable plaque.
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