The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

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Summary

It is shown in a mouse autoimmune model that local Mrp8 and Mrp14 production is essential for the induction of autoreactive CD8+ T cells and the development of systemic autoimmunity.

Type
article
Published
2010-06-01
Cited by
307
References
30

Keywords

Autoimmunity, Immunology, Downregulation and upregulation, CD8, Receptor

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