Are MHC-bound peptides a nuisance for positive selection?
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Summary
It is argued that the T cell receptor (TCR) would prefer to see empty M HC molecules to achievePositive selection, and a role for empty class I mole- cules in positive selection is excluded on these grounds.
- Type
- review
- Published
- 1994-12-01
- Cited by
- 70
- References
- 20
- OpenAlex
- https://openalex.org/W2023249971
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36166737
Keywords
Nuisance, Biology, Selection (genetic algorithm), Major histocompatibility complex, Computational biology
References
- Thermal stability comparison of purified empty and peptide-filled forms of a class I MHC molecule.
- Cell biology of antigen processing and presentation to major histocompatibility complex class I molecule-restricted T lymphocytes.
- T cell receptor antagonist peptides induce positive selection.
- Mutations in the major histocompatibility complex class I antigen‐presenting groove affect both negative and positive selection of T cells
- Peptides naturally presented by MHC class I molecules.
- TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.
- Positive and negative thymocyte selection induced by different concentrations of a single peptide.
- The effects of MHC gene dosage and allelic variation on T cell receptor selection.
- Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
- Evidence for a differential avidity model of T cell selection in the thymus.
- HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides
- Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells
- Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture
- Specificity and flexibility in thymic selection
- Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus.
- HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.
- It is easier for a camel to pass the needle's eye.
- Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection.
- The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2.
Cited by
- The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.
- BALB/c invariant chain mutant mice display relatively efficient maturation of CD4+ T cells in the periphery and secondary proliferative responses elicited upon peptide challenge.
- Unexpected reactivities of T cells selected by a single MHC-peptide ligand.
- In thymic selection, peptide diversity gives and takes away.
- Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance.
- What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity?
- MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span.
- Thymic stromal cells and positive selection
- Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells.
- Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules
- Mice Lacking Terminal Deoxynucleotidyl Transferase: Adult Mice with a Fetal Antigen Receptor Repertoire
- Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus
- Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR.
- T-cell repertoire: political correctness in the immune system.
- The imprint of intrathymic self-peptides on the mature T cell receptor repertoire.
- Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.
- The repertoire of T cells shaped by a single MHC/peptide ligand.
- Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide
- The agonist-antagonist balance in positive selection.
- Identification of a naturally occurring ligand for thymic positive selection.
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