Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning
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Summary
A new method for predicting class II major histocompatibility complex-binding peptides is described, based on the preferences observed in a systematic series of peptide binding experiments, which hold implications for the design of subunit vaccines and in the identification of autoantigenic peptide regions within self proteins.
- Type
- article
- Published
- 1994-12-01
- Cited by
- 310
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W2021002908
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7529973
Keywords
Epitope, Peptide, Major histocompatibility complex, Peptide sequence, Computational biology
References
- A sequence pattern common to T cell epitopes.
- Peptide binding to HLA‐DR1: a peptide with most residues substituted to alanine retains MHC binding.
- Selection of T cell epitopes and vaccine engineering.
- HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions.
- Prediction of immunodominant helper T cell antigenic sites from the primary sequence.
- Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).
- Conformational and structural characteristics of peptides binding to HLA-DR molecules.
- A molecular basis for MHC class II--associated autoimmunity.
- Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin
- Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.
- Promiscuous and allele-specific anchors in HLA-DR-binding peptides.
- Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
- Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
- Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
- MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.
- A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis
- Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.
- Identification of a motif for HLA-DR1 binding peptides using M13 display libraries
- MHC class-II molecules and autoimmunity.
- Brief Definitive Report
Cited by
- Synthetic malaria peptide vaccine elicits high levels of antibodies in vaccinees of defined HLA genotypes.
- Assessment of clonality of rosetting T lymphocytes in Hodgkin's disease by single-cell polymerase chain reaction: detection of clonality in a polyclonal background in a case of lymphocyte predominance Hodgkin's disease
- Is there a role for microorganisms in the pathogenesis of sarcoidosis?
- In silico predictions; in vivo veritas
- Application of Genetic Search in Derivation of Matrix Models of Peptide Binding to MHC Molecules
- Immune Responses to Homocitrullinated Protein/ Peptide in Rheumatoid Arthritis
- Identifizierung krankheitsassoziierter MHC-Liganden durch massenspektrometrische Verfahren
- Influence du ligand peptidique sur la conformation et la stabilité des molécules du complexe majeur d'histocompatibilité de classe II
- From Basic Immunology to Immune-Mediated Demyelination
- Methods for Prediction of Peptide Binding to MHC Molecules: A Comparative Study
- Molecular mimicry and Lyme arthritis.
- T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental Agents
- Predicting sequences and structures of MHC-binding peptides: a computational combinatorial approach
- Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition.
- The T-cell response in patients with cancer.
- Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.
- Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?
- Peptidomimetic compounds that inhibit antigen presentation by autoimmune disease-associated class II major histocompatibility molecules
- HLA class II peptide binding specificity and autoimmunity.
- Major histocompatibility complex-directed susceptibility to rheumatoid arthritis.
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