Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition.
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Summary
It is demonstrated that the complementarity-determining region 3 loops contribute to the degree of degeneracy in peptide recognition by human MBP-specific TCRs.
- Type
- article
- Published
- 1999-01-01
- Cited by
- 77
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W1509401982
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25398037
Keywords
T-cell receptor, Degree (music), Degeneracy (biology), Peptide, Computational biology
References
- The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA.
- Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.
- Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2.
- An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex
- Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
- Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System
- The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families.
- Activation of autoreactive T cells by peptides from human pathogens
- Molecular mimicry and autoimmune disease.
- Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
- Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning
- Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen
- Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands.
- Essential flexibility in the T-cell recognition of antigen
- Expression of Recombinant HLA-DR2 Molecules
- Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
- Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
- Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes.
- A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex
- Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein
Cited by
- T Cell Tolerance Based on Avidity Thresholds Rather Than Complete Deletion Allows Maintenance of Maximal Repertoire Diversity1
- The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination.
- Peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis.
- Vaccination against Her2/neu - expressing cancer using chimeric virus-like particles
- Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II Molecules
- T-Cell Therapy: Options for Infectious Diseases
- Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease
- Systematic Analysis of the Combinatorial Nature of Epitopes Recognized by TCR Leads to Identification of Mimicry Epitopes for Glutamic Acid Decarboxylase 65-Specific TCRs1
- Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis
- The CD8+ T cell repertoire against Her‐2/neu antigens in neu transgenic mice is of low avidity with antitumor activity
- Deconstructing the peptide-MHC specificity of T cell recognition
- Immunogenic HER-2/neu peptides as tumor vaccines
- Structural Alterations in peptide–MHC Recognition by Self-reactive T cell Receptors
- How an autoimmune reaction triggered by molecular mimicry between streptococcal M protein and cardiac tissue proteins leads to heart lesions in rheumatic heart disease.
- Cross-immune tolerance: conception and its potential significance on transplantation tolerance
- The autoimmune TCR-Ob.2F3 can bind to MBP85-99/HLA-DR2 having an unconventional mode as in TCR-Ob.1A12.
- MHC restriction: slip-sliding away
- Molecular Mimicry as a Mechanism of Autoimmune Disease
- Multiple sclerosis: Genomic rewards
- Individual MHCI-Restricted T-Cell Receptors are Characterized by a Unique Peptide Recognition Signature
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