Selection of T cell epitopes and vaccine engineering.
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Summary
The chapter describes assays for identifying peptides that bind to human major histocompatibility complex (MHC) class II antigens that are likely to be useful immunogens.
- Type
- article
- Published
- 1991-01-01
- Cited by
- 45
- References
- 26
- OpenAlex
- https://openalex.org/W935441764
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28017967
Keywords
Immunogenicity, Epitope, Peripheral blood mononuclear cell, Major histocompatibility complex, Biology
References
- Binding of immunogenic peptides to Ia histocompatibility molecules
- Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.
- Rationale for the development of an engineered sporozoite malaria vaccine.
- Human T cells recognize polymorphic and non‐polymorphic regions of the Plasmodium falciparum circumsporozoite protein.
- THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.
- An invariant, "universal" T-cell epitope in the P. falciparum circumsporozoite protein.
- Nonpolymorphic regions of p190, a protein of the Plasmodium falciparum erythrocytic stage, contain both T and B cell epitopes.
- Detection of a novel human class II HLA antigen
- New coupling reagents in peptide chemistry
- Antigen recognition by class I-restricted T lymphocytes.
- Automated synthesis of peptides.
- Epitopes recognized by human t lymphocytes on malaria circumsporozoite protein
- A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules
- HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides
- Structural model of HLA-DR1 restricted T cell antigen recognition.
- Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum.
- Proliferative response of human lymphocytes to antigens not experienced in vivo.
- In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.
- Analysis by sequential immunoprecipitations of the specificities of the monoclonal antibodies TU22,34,35,36,37,39,43,58 and YD1/63.HLK directed against human HLA class II antigens.
- Isolation and characterization of antigen-Ia complexes involved in T cell recognition.
Cited by
- T cell epitope characterization in tandemly repetitive Trypanosoma cruzi B13 protein.
- T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental Agents
- HLA class II peptide binding specificity and autoimmunity.
- Human T cell responses to a semi-conserved sequence of the malaria vaccine candidate antigen MSP-1
- Multispecific CD4+ T Cell Response to a Single 12-mer Epitope of the Immunodominant Heat-Shock Protein 60 of Yersinia enterocolitica in Yersinia-Triggered Reactive Arthritis: Overlap with the B27-Restricted CD8 Epitope, Functional Properties, and Epitope Presentation by Multiple DR Alleles1
- Promiscuous T-cell epitopes of Plasmodium Merozoite Surface Protein 9 (PvMSP9) induces IFN-γ and IL-4 responses in individuals naturally exposed to malaria in the Brazilian Amazon
- Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys
- Hepatitis B surface antigen presentation and HLA‐DRB1*– lessons from twins and peptide binding studies
- Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DRbeta1*03 molecules induces antibody production and protection.
- High non-protective, long-lasting antibody levels in malaria are associated with haplotype shifting in MHC-peptide-TCR complex formation: a new mechanism for immune evasion.
- Identification of a signaling complex involving CD2, ζ chain and p59fyn in T lymphocytes
- A fungal metabolite which inhibits the interaction of CD4 with major histocompatibility complex‐encoded class II molecules
- Identification and evaluation of universal epitopes in Plasmodium vivax Duffy binding protein.
- MHC allele-specific binding of a malaria peptide makes it become promiscuous on fitting a glycine residue into pocket 6.
- Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning
- Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase
- Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association
- Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen MAGE-3.
- Structural characterisation of sporozoite components for a multistage, multi-epitope, anti-malarial vaccine.
- Promiscuous and allele-specific anchors in HLA-DR-binding peptides.
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