Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
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Summary
A dimer of the class II αβ heterodimers is seen in the crystal forms of HLA-DR1, suggesting class II HLA dimerization as a mechanism for initiating the cytoplasmic signalling events in T-cell activation.
- Type
- article
- Published
- 1993-07-01
- Cited by
- 2,332
- References
- 68
- OpenAlex
- https://openalex.org/W2080956086
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4248668
Keywords
Human leukocyte antigen, Major histocompatibility complex, Dimer, Groove (engineering), Histocompatibility
References
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- Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides.
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- A graphics model building and refinement system for macromolecules
- Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
- Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle
Cited by
- The role of N-linked oligosaccharides of MHC class II antigens in T cell stimulation.
- Evolution of MHC Class II Allelic Diversity
- Characterization and epitope mapping of four HLA class II reactive mouse monoclonal antibodies using transfected L cells and human cells transfected with mutants of DQB1*0302.
- Accuracy of a structural homology model for a class II histocompatibility protein, HLA-DR1: comparison to the crystal structure.
- Macaques immunized with HLA-DR are protected from challenge with simian immunodeficiency virus
- Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma
- A peptide binding weakly to the major histocompatibility molecule augments T cell responses
- Rapid allelic diversification and intensified selection at antigen recognition sites of the Mhc class II DPB1 locus during hominoid evolution.
- Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site.
- Antigen-specific inhibition of CD4+ T-cell responses to β-lactoglobulin by its single amino acid-substituted mutant form through T-cell receptor antagonism
- Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease.
- Variation on islands: major histocompatibility complex (Mhc) polymorphism in populations of the Australian bush rat
- Amino Acid Substitutions in the Putative MHC Class II “Dimer of Dimers” Interface Inhibit CD4+ T Cell Activation
- Major histocompatibility complex (MHC) variation in the endangered Mexican wolf and related canids1
- Design, Engineering, and Production of Human Recombinant T Cell Receptor Ligands Derived from Human Leukocyte Antigen DR2*
- Interactions between MHC molecules and co-receptors of the TCR.
- Novel HLA-DRB1 alleles discovered during routine sequencing based typing, DRB1*03052, DRB1*04032, DRB1*1139 and DRB1*1346.
- Protective effect of DRB1 locus against type 2 diabetes mellitus in Mexican Mestizos.
- Extensive polymorphism and different evolutionary patterns of intron 2 were identified in the HLA-DQB1 gene
- A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution
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