MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.
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Summary
Transplantation of wild-type bone marrow cells rescues vascularization and ossification in gelatinase B-null growth plates, indicating that these processes are mediated by gelatinaseB-expressing cells of bone marrow origin, designated chondroclasts.
- Type
- article
- Published
- 1998-05-01
- Cited by
- 1,826
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2016411107
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9106947
Keywords
Biology, Angiogenesis, Ossification, Gelatinase, Gelatinase A
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- Tumor cell intravasation alu-cidated: the chick embryo opens the window.
- Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: implications for angiogenesis.
- Spatiotemporal change of rat collagenase (MMP-13) mRNA expression in the development of the rat femoral neck
- Matrix metalloproteinases: pro- and anti-angiogenic activities.
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- Matrix metalloproteinase-9 in lung remodeling.
- In situ Detection of Gelatinolytic Activity in Skin Specimens of Squamous Cell Carcinoma: Probable Role in Dyskeratosis and Tumor Invasion
- A lethal complication of central venous catheterisation.
- Developmental aspects of fracture healing and the use of pharmacological agents to alter healing.
- Inhibition of lymphangiogenesis‐related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270
- Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases.
- Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice
- Measurement of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP) in blood and urine: potential clinical applications.
- The combination of Jun N-terminal kinase inhibitor and TNP-470 blocks carcinosarcoma-induced endothelial cell tube formation in a synergistic manner.
- Endostatin promotes the anabolic program of rabbit chondrocyte
- Matrix Metalloproteinases Are Not Essential for Aggrecan Turnover during Normal Skeletal Growth and Development
- Effect of Chronic Wound Exudates and MMP-2/-9 Inhibitor on Angiogenesis In Vitro
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