Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
Explore this paper's citation graph
Summary
In vitro application of Hedgehog or P THrP protein to normal or PTHrP (−/−) limb explants demonstrated that PTHRP mediates the effects of Ihh through the formation of a negative feedback loop that modulates the rate of chondrocyte differentiation.
- Type
- article
- Published
- 1996-08-02
- Cited by
- 2,054
- References
- 58
- OpenAlex
- https://openalex.org/W1995499476
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27737023
Keywords
Indian hedgehog, Parathyroid hormone-related protein, Chondrocyte, Hedgehog signaling pathway, Hedgehog
References
- Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo
- The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.
- Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.
- Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors
- Tissue-specific forms of type IX collagen-proteoglycan arise from the use of two widely separated promoters.
- The type X collagen gene. Intron sequences split the 5'-untranslated region and separate the coding regions for the non-collagenous amino-terminal and triple-helical domains.
- Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.
- c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development.
- Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia.
- A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.
- Role of the Drosophila patched gene in positional signalling
- Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud.
- Nucleotide sequence of a parathyroid hormone-related peptide expressed by the 10 day chicken embryo.
- The Drosophila patched gene encodes a putative membrane protein required for segmental patterning.
- Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation
- Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
- A series of normal stages in the development of the chick embryo. 1951.
- Retroviral infection coupled with tissue transplantation limits gene transfer in the chicken embryo.
- Mutations affecting segment number and polarity in Drosophila
- A molecular pathway determining left-right asymmetry in chick embryogenesis.
Cited by
- The Molecular Genetics of Bone Formation
- BMP-5 deficiency alters chondrocytic activity in the mouse proximal tibial growth plate.
- Corin, a Mosaic Transmembrane Serine Protease Encoded by a Novel cDNA from Human Heart*
- Cell cycle genes in chondrocyte proliferation and differentiation.
- Expression of FGFR3 with the G380R Achondroplasia Mutation Inhibits Proliferation and Maturation of CFK2 Chondrocytic Cells
- Aquaporin-5 expression, but not other peripheral lung marker genes, is reduced in PTH/PTHrP receptor null mutant fetal mice.
- Cell cycle control in growth plate chondrocytes.
- Effects of Hedgehog Proteins on Tissue Engineering of Cartilage in Vitro
- Discovery of Sonic hedgehog expression in postnatal growth plate chondrocytes: Differential regulation of Sonic and Indian hedgehog by retinoic acid
- Molecular mechanisms underlying limb anomalies associated with cholesterol deficiency during gestation: implications of Hedgehog signaling.
- Secondary chondrocyte-derived Ihh stimulates proliferation of periosteal cells during chick development
- Hepatocyte Aggregates: Methods of Preparation in the Microgravity Simulating Bioreactor Use in Tissue Engineering
- Developmental actions of natriuretic peptides in the brain and skeleton
- Agrin is highly expressed by chondrocytes and is required for normal growth
- Developmental patterns of cartilage.
- Regulation of osteogenic differentiation during skeletal development.
- Wnt and hedgehog signaling pathways in bone development.
- A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.
- Induction and patterning of intramembranous bone.
- Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and Aging
Related papers
- Immunohistochemical detection of parathyroid hormone-related peptide, Indian hedgehog, and patched in the process of endochondral ossification in the human
- Indian hedgehog signaling in osteosarcoma: Co-expression of GLI1, PTCH1, and IHH
- Distribution of genes for parathyroid hormone (PTH)-related peptide, Indian hedgehog, PTH receptor and patched in the process of experimental spondylosis in mice.
- Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish.
- Organization of the Indian hedgehog – parathyroid hormone-related protein system in the postnatal growth plate
- Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation
- The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched.
- The role of hedgehog signaling during gastric regeneration
- Hedgehog signaling in capillary formation
- A Sonic Hedgehog-Gli-Bmi1 signaling pathway plays a critical role in p27 deficiency induced bone anabolism