Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema.
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Summary
According to recently proposed pathogenic models in COPD and IPF, premature cellular senescence likely affects distinct progenitors cells, leading to stem cell exhaustion, with emphasis on the possible molecular and cellular mechanisms leading to the severe parenchymal remodeling that characterizes, in different ways, these deadly diseases.
- Type
- article
- Published
- 2013-09-01
- Cited by
- 303
- References
- 262
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012919184
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205498887
Keywords
Idiopathic pulmonary fibrosis, COPD, Lung, Medicine, Pulmonary fibrosis
References
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- Airway Epithelial Cell Senescence in the Lung Allograft
Cited by
- Telomeres in lung diseases.
- Lung cryobiopsies: A paradigm shift in diagnostic bronchoscopy?
- The Senile Lung as a Possible Source of Pitfalls on Chest Ultrasonography and Computed Tomography
- PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis
- Features and outcome of familial idiopathic pulmonary fibrosis.
- Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model.
- Optimizing Treatment of Elderly COPD Patients: What Role for Inhaled Corticosteroids?
- Combined pulmonary fibrosis and emphysema: an increasingly recognized condition
- Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease.
- Diagnostic Values For Club Cell Secretory Protein (CC16) in Serum of Patients of Combined Pulmonary Fibrosis and Emphysema
- The epithelium in idiopathic pulmonary fibrosis: breaking the barrier
- Cellular senescence: from physiology to pathology
- Translational research on aging: clinical epidemiology as a bridge between the sciences
- Mechanistic Links between Aging and Lung Fibrosis
- Pirfenidone for the treatment of idiopathic pulmonary fibrosis
- H4 Antagonist, JNJ 39758979, Inhibits Histamine-Induced Pruritus in the Clinic
- Role of cellular senescence and NOX4-mediated oxidative stress in Systemic Sclerosis pathogenesis.
- Age-Related Changes in the Cellular Composition and Epithelial Organization of the Mouse Trachea
- Interstitial lung disease
- Autophagy and senescence in fibrosing cholangiopathies.
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