Phagosome dynamics and function
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Summary
Although most phagocytosed microorganisms are killed in the lysosome, some pathogens have developed survival strategies and are able to live in the harsh conditions in the phagolysosome or interfere with the maturation process and thereby evade destruction by acid hydrolases.
- Type
- review
- Published
- 2000-03-01
- Cited by
- 187
- References
- 85
- OpenAlex
- https://openalex.org/W2099288361
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37438504
Keywords
Phagolysosome, Phagosome, Cell biology, Endocytic cycle, Endosome
References
- Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages
- Recombinant Escherichia coli express a defined, cytoplasmic epitope that is efficiently processed in macrophage phagolysosomes for class II MHC presentation to T lymphocytes.
- Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.
- Transport of phagosomal components to an endosomal compartment.
- IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.
- Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells.
- Vacuolar ATPase activity is required for endosomal carrier vesicle formation.
- Characterization and subcellular localization of target membrane soluble NSF attachment protein receptors (t-SNAREs) in macrophages. Syntaxins 2, 3, and 4 are present on phagosomal membranes.
- Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis.
- Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.
- Molecular characterization of phagosomes.
- Fusion of newly formed phagosomes with endosomes in intact cells and in a cell-free system.
- Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.
- Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.
- Activation of Phagocytic Cells' C3 Receptors for Phagocytosis
- Localization and activity of various lysosomal proteases in Leishmania amazonensis-infected macrophages
- Internalized Listeria monocytogenes modulates intracellular trafficking and delays maturation of the phagosome.
- Lysosome recruitment during host cell invasion by Trypanosoma cruzi.
- Mycobacterium and Leishmania: stowaways in the endosomal network.
- Invasion of vertebrate cells by Toxoplasma gondii.
Cited by
- Role of the Yersinia protein YopK in microbe-host interactions
- The links between membrane actin assembly by mycobacterial phagosomes and phagosome maturation, macrophage activation and pathogen killing
- Phosphoinositide involvement in phagocytosis and phagosome maturation.
- Antiphagocytosis by Yersinia pseudotuberculosis : role of the YopH target proteins
- Decoupling Internalization, Acidification and Phagosmal-Endosomal/Iysosomal Phagocytosis of Internalin A coated Beads in epithelial cells
- Intracellular pathogens in membrane interactions and vacuole biogenesis
- Effects of invasin and YopH of Yersinia pseudotuberculosis on host cell signaling
- Immune regulation of the host autophagic response and the elimination of Mycobacterium tuberculosis
- Cellular mechanisms of bacterial internalization counteracted by Yersinia.
- Functional microtubules are required for antigen processing by macrophages and dendritic cells.
- Acidification and protein traffic.
- Impaired Host Defense in Mice Lacking ONZIN1
- P2Y(6)-Evoked Microglial Phagocytosis.
- In-silico analysis of PtpA - an antigenic protein of Mycobacterium tuberculosis
- Increase in Phagocytosis after Geldanamycin Treatment or Heat Shock: Role of Heat Shock Proteins1
- Phagocytosis and Phagosome Maturation Are Regulated by Calcium in J774 Macrophages Interacting with Unopsonized Prey
- Modeling of cell signaling pathways in macrophages by semantic networks
- Quantitative Proteomic Approaches for the Analysis of Human Lung Samples in Pulmonary Sarcoidosis
- Localized Exocytosis of Primary (Lysosomal) Granules During Phagocytosis: Role of Ca2+-Dependent Tyrosine Phosphorylation and Microtubules1
- Phagocytosis and the actin cytoskeleton.
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