Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity
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Summary
It is demonstrated that multiple effector mechanisms including H2A ubiquitination and chromatin compaction combine to mediate PRC1-dependent repression of genes that are crucial for the maintenance of ESC identity.
- Type
- article
- Published
- 2012-07-01
- Cited by
- 267
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011753829
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5021143
Keywords
PRC2, Biology, Polycomb-group proteins, Chromatin, Histone
References
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- Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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- Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.
- Chromatin signatures of pluripotent cell lines
- Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification
- Spatial preservation of nuclear chromatin architecture during three-dimensional fluorescence in situ hybridization (3D-FISH).
- Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells
- Production of Monoclonal Antibodies Against Mammalian Ring1B Proteins
- Dissociation of mammalian Polycomb-group proteins, Ring1B and Rae28/Ph1, from the chromatin correlates with configuration changes of the chromatin in mitotic and meiotic prophase
- Ubiquitin E3 Ligase Ring1b/Rnf2 of Polycomb Repressive Complex 1 Contributes to Stable Maintenance of Mouse Embryonic Stem Cells
- The ground state of embryonic stem cell self-renewal
- Role of histone H2A ubiquitination in Polycomb silencing
- The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity.
- Transcriptional activation of polycomb-repressed genes by ZRF1
- Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.
- Histone ubiquitination and chromatin remodeling in mouse spermatogenesis.
Cited by
- Hematopoietic stem cell development: an epigenetic journey.
- The Epigenetic Paradox of Pluripotent ES Cells.
- Role of aberrant protein modification, assembly, and localization in cloned embryo phenotypes.
- H3K9/HP1 and Polycomb: two key epigenetic silencing pathways for gene regulation and embryo development.
- The molecular mechanism of the aberrant expression of the B-cell specific PAX5 gene in t(8;21) AML
- Influence of CpG islands on chromatin structure
- Méthylations de l'histone H3 et contrôle épigénétique des propriétés des cellules souches de gliomes
- The role of chromatin organization and structure in neuronal differentiation
- Mammalian epigenetic mechanisms
- The role of Polycomb-mediated epigenetic regulation in embryonic stem cell differentiation
- Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications
- Functional analysis of the histone variant H2A.Z during lineage commitment
- Hox genes regulation in vertebrates
- Cell Type Dependent Effects on HSV Transcription
- The interplay of histone modifications – writers that read
- Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.
- The quest for mammalian Polycomb response elements: are we there yet?
- The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development
- Hox gene regulation and timing in embryogenesis.
- Histone Methylation in the Nervous System: Functions and Dysfunctions
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