The ground state of embryonic stem cell self-renewal
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Summary
It is shown that extrinsic stimuli are dispensable for the derivation, propagation and pluripotency of ES cells and reveal that ES cells have an innate programme for self-replication that does not require extrinsics instruction.
- Type
- article
- Published
- 2008-05-22
- Cited by
- 3,533
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2058521801
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4425274
Keywords
Embryonic stem cell, Cell biology, Induced pluripotent stem cell, Biology, Stem cell
References
- Defined conditions for neural commitment and differentiation.
- Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.
- Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.
- Self-renewal of teratocarcinoma and embryonic stem cells
- The genesis of embryonic stem cells
- Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
- BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3.
- Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.
- Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination
- A novel mechanism for regulating clonal propagation of mouse ES cells
- STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
- FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
- LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
- Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.
- Establishment in culture of pluripotential cells from mouse embryos
- The selectivity of protein kinase inhibitors: a further update.
- Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways.
- Specificity and mechanism of action of some commonly used protein kinase inhibitors.
- Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells.
- Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.
Cited by
- Key Players in the Gene Networks Guiding ESCs toward Mesoderm
- Optimization of Culture Conditions for Maintaining Porcine Induced Pluripotent Stem Cells
- Identification of an ES cell pluripotent state-specific DUSP6 enhancer.
- Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells
- The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host–parasite interaction
- Fluid shear stress primes mouse embryonic stem cells for differentiation in a self‐renewing environment via heparan sulfate proteoglycans transduction
- Integrating post‐transcriptional regulation into the embryonic stem cell gene regulatory network
- esBAF safeguards Stat3 binding to maintain pluripotency
- Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions
- Signaling Roadmap Modulating Naive and Primed Pluripotency
- Mitotic and mitogenic Wnt signalling
- Epigenetic regulation of the neuroblastoma genes, Arid3b and Mycn
- Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF
- A double take on bivalent promoters.
- Statistical mechanics of pluripotency.
- Sox2 Expression Is Regulated by a Negative Feedback Loop in Embryonic Stem Cells That Involves AKT Signaling and FoxO1
- Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment
- Zfp322a Regulates Mouse ES Cell Pluripotency and Enhances Reprogramming Efficiency
- Differential effects of Akt isoforms on somatic cell reprogramming
- The post-inner cell mass intermediate: implications for stem cell biology and assisted reproductive technology.
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