A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
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Summary
A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library and its similarity to functional telomeres isolated from lower eukaryotes suggest that this sequence is a functional human telomere.
- Type
- article
- Published
- 1988-09-01
- Cited by
- 2,338
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W2010882280
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23675465
Keywords
Telomere, Biology, Repeated sequence, DNA, Chromosome
References
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Cited by
- Development of an shRNA screen to identify mediators of cellular senescence in human breast epithelial cells
- A mammalian factor that binds telomeric TTAGGG repeats in vitro
- Characterization of swine short interspersed repetitive sequences.
- Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
- Many yeast chromosomes lack the telomere-specific Y' sequence
- Noncanonical structures and their thermodynamics of DNA and RNA under molecular crowding: beyond the Watson-Crick double helix.
- DNA G-Quadruplexes, Telomere-Specific Proteins and Telomere-Associated Enzymes as Potential Targets for New Anticancer Drugs
- A novel minisatellite at a cloned hamster telomere
- Murine radiation myeloid leukaemogenesis: Relationship between interstitial telomere‐like sequences and chromosome 2 fragile sites
- Mechanisms of MRP over‐expression in four human lung‐cancer cell lines and analysis of the MRP amplicon
- A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q
- Fluorescent in situ hybridization of the telomere repeat sequence in hamster sperm nuclear structures
- Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains.
- Replicative Potential and Telomere Length in Human Skeletal Muscle: Implications for Satellite Cell-Mediated Gene Therapy
- Normal telomere maintenance in immortal ataxia telangiectasia cell lines.
- Telomerase RNA expression during progression of gastric cancer.
- Telomerase activity in cancer as a diagnostic and therapeutic target.
- Induction of telomerase activity in fibroblasts from bleomycin-injured lungs.
- Transient increase in telomerase activity of proliferating fibroblasts and endothelial cells in granulation tissue of the human skin
- Telomere maintenance and cancer ? look, no telomerase
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