Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors.
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Summary
By offering a tenfold increase in the size of the DNA molecules that can be cloned into a microbial host, this system addresses a major gap in existing experimental methods for analyzing complex DNA sources.
- Type
- article
- Published
- 1987-05-15
- Cited by
- 1,369
- References
- 36
- OpenAlex
- https://openalex.org/W2021608281
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46031127
Keywords
Yeast artificial chromosome, DNA, Cloning (programming), Biology, Yeast
References
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- Long-range restriction site mapping of mammalian genomic DNA
- Characterization of the human factor VIII gene
Cited by
- Construction of a mouse yeast artificial chromosome library in a recombination–deficient strain of yeast
- Chromosome fishing: an affinity capture method for selective enrichment of large genomic DNA fragments.
- Yeast telomere repeat sequence (TRS) improves circular plasmid segregation, and TRS plasmid segregation involves the RAP1 gene product
- A human Chromosome 7-specific genomic DNA library in yeast artificial chromosomes
- A genome approach to the human X chromosome.
- Strategies for the genetic manipulation of Saccharomyces cerevisiae.
- A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC.
- Preparation of clone libraries in yeast artificial-chromosome vectors.
- Generation of large insert YAC libraries.
- A novel minisatellite at a cloned hamster telomere
- Marker enrichment and high-resolution map of the segment of potato chromosome VII harbouring the nematode resistance gene Gro1
- Entamoeba histolytica: gene linkage groups and relevant features of its karyotype
- Genomic organization and chromosomal localization of the human casein gene family
- Towards the physical map of the Trypanosoma cruzi nuclear genome: construction of YAC and BAC libraries of the reference clone T. cruzi CL-Brener.
- Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes.
- Factors influencing the successful production of large plasmids for use in gene therapy and DNA vaccination.
- Efficient Generation of Transgenic Mice with Intact Yeast Artificial Chromosomes by Intracytoplasmic Sperm Injection1
- Defined physical limits of the Huntington disease gene candidate region.
- From linkage to genes : positional cloning.
- Construction and characterisation of a yeast artificial chromosome library containing five haploid sugarbeet (Beta vulgaris L.) genome equivalents
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