Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
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Summary
A new basis for the construction of a genetic linkage map of the human genome is described, to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms, when hybridized to restriction digests of an individual's DNA.
- Type
- article
- Published
- 1980-05-01
- Cited by
- 8,577
- References
- 67
- Access
- Open access
- OpenAlex
- https://openalex.org/W1803375514
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6288852
Keywords
Genetics, Biology, Genetic linkage, Restriction fragment length polymorphism, Locus (genetics)
References
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- Human Red Cell Peptidases
- Data on the incidence, segregation and linkage relations of the adenylate kinase (AK) polymorphism
- Further studies on the genetics of placental alkaline phosphatase
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- The single-copy DNA sequence polymorphism of the sea urchin Strongylocentrotus purpuratus.
- MNSs Gene Frequencies in English Blood Donors
- Conservation of cytoplasmic poly(A)-containing RNA in mouse and rat
- Cloning of the yeast tyrosine transfer RNA genes in bacteriophage lambda.
- A general model for the genetic analysis of pedigree data.
Cited by
- Preliminary ordering of multiple linked loci using pairwise linkage data
- Sib-Pair Analysis of Adenosine Deaminase Locus in NIDDM
- The human genome project and medical genetics.
- The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization
- Multiple restriction fragment length polymorphisms at the GLUT2 locus: GLUT2 haplotypes for genetic analysis of Type 2 (non-insulin-dependent) diabetes mellitus
- A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.
- Carrier identification of cystic fibrosis by recombinant DNA techniques.
- DNA finger printing by oligonucleotide probes specific for simple repeats
- Simultaneous analysis of multiple polymorphic loci using amplified sequence polymorphisms (ASPs).
- The human "interferon-beta 2/hepatocyte stimulating factor/interleukin-6" gene: DNA polymorphism studies and localization to chromosome 7p21.
- Mapping and sequencing the human genome.
- Disease diagnosis by recombinant DNA methods.
- Genetics, Genomics and Breeding of Sunflower
- Blot hybridisation analysis of genomic DNA.
- Population genetics and forensic applications using multiplex PCR (CSF1PO, TPOX, and TH01) loci in the Basque Country.
- Sex chromosome-specific DNA sequences.
- Possible linkage of a breast cancer‐susceptibility locus to the ABO locus: Sensitivity of LOD scores to a single new recombinant observation
- Methods to analyse the human genome
- Analysis of DNA restriction fragments and polymerase chain reaction products by capillary electrophoresis.
- On the trail of genetic culprits in Williams syndrome.
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