Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.
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Summary
Mouse chimeras derived from embryonic stem cells with a disrupted beta 2M gene transmitted the inactivated gene to their progeny and these animals are grossly deficient in CD4- CD8+ T cells, which normally mediate cytotoxic T cell function.
- Type
- article
- Published
- 1990-06-08
- Cited by
- 924
- References
- 41
- OpenAlex
- https://openalex.org/W2010315866
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21217903
Keywords
Cytotoxic T cell, Biology, CD8, Molecular biology, Antigen
References
- Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.
- Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells
- Development of CD4−CD8+ cytotoxic T cells requires interactions with class I MHC determinants
- T cell tolerance by clonal elimination in the thymus.
- An Fc receptor structurally related to MHC class I antigens
- Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
- MHC antigens in urine as olfactory recognition cues
- Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
- Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen
- Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens.
- Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.
- Analysis of Qa-2 antigen expression by preimplantation mouse embryos: possible relationship to the preimplantation-embryo-development (Ped) gene product.
- In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells
- Thymotaxin, a chemotactic protein, is identical to beta 2-microglobulin.
- Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.
- Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination.
- Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
- The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells.
- Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse
- Molecular association between major histocompatibility complex class I antigens and insulin receptors in mouse liver membranes.
Cited by
- Expression and characterization of recombinant mouse beta 2-microglobulin type a in insect cells infected with recombinant baculoviruses.
- Downregulation of peptide transporter genes in cell lines transformed with the highly oncogenic adenovirus 12
- A combined approach for quantitation of each specific HLA-A or -B antigen expressed on cells.
- Sensitization of CD8 T Cells During Acute Viral Infections Impacts Bystander and Latecomer CD8 T Cell Responses : A Dissertation
- Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant
- Reactivity and Specificity of CD8+ T Cells in Mice with Defects in the MHC Class I Antigen‐Presenting Pathway
- Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.
- Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission
- Collaboration of Antibody and Inflammation in Clearance of Rabies Virus from the Central Nervous System
- The murine buccal mucosa is an inductive site for priming class I‐restricted CD8+ effector T cells in vivo
- Regulation of lineage commitment distinct from positive selection.
- Human CD4 residue Phe 43 is critical for repertoire development and maturation of MHC class II restricted CD4 single‐positive T lineage cells in vivo
- Lethal host-versus-graft disease and hypereosinophilia in the absence of MHC I-T-cell interactions.
- αβTCR+ Cells Are a Minimal Fraction of Peripheral CD8+ Pool in MHC Class I-Deficient Mice1
- Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection.
- Development and selection of T cells: facts and puzzles.
- Pathogenesis of experimental tuberculosis in animal models.
- Immune Mechanisms Responsible for Vaccination against and Clearance of Mucosal and Lymphatic Norovirus Infection
- Lymphocytes genetically modified to express tumor antigens target dendritic cells in vivo and induce antitumor immunity
- Secretory IgA inhibits Pseudomonas aeruginosa binding to cornea and protects against keratitis.
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