T cell tolerance by clonal elimination in the thymus.

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Summary

The results show that in normal animals tolerance to self-MHC is due to clonal elimination rather than suppression, and indicate that tolerance induction may occur in the thymus at the time immature thymocytes are selected to move into the mature thymocyte pool.

Type
article
Published
1987-04-24
Cited by
2,325
References
37

Keywords

Biology, Thymocyte, Clonal deletion, T-cell receptor, T cell

References

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