Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications.
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Summary
Despite the suitability of both CDs as siRNA delivery vectors in terms of their ability to complex siRNA and the properties of the complexes yielded, only one CD achieved good transfection efficiency, likely due to the differences in their chemical structures.
- Type
- article
- Published
- 2012-12-18
- Cited by
- 26
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W1996840333
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8569324
Keywords
Gene silencing, Transfection, Chemistry, Gene knockdown, MTT assay
References
- Therapeutic targeting in the silent era: advances in non-viral siRNA delivery.
- Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery.
- Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins
- Cationic beta-cyclodextrin bilayer vesicles.
- Lipoplex morphologies and their influences on transfection efficiency in gene delivery.
- Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles.
- A click chemistry route to 2-functionalised PEGylated and cationic β-cyclodextrins: co-formulation opportunities for siRNA delivery.
- Profiling RNA interference (RNAi)‐mediated toxicity in neural cultures for effective short interfering RNA design
- Physicochemical and Biological Evaluation of siRNA Polyplexes Based on PEGylated Poly(amido amine)s
- Amphiphilic Cyclodextrins – Advances in Synthesis and Supramolecular Chemistry
- Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles.
- Cationic cyclodextrin amphiphiles as gene delivery vectors
- Poly-6-cationic amphiphilic cyclodextrins designed for gene delivery.
- Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrPC on Neuronal Cells and PrPRES in Infected Cell Cultures
- RNAi therapeutics: a potential new class of pharmaceutical drugs
- Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders.
- Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice.
- Physico-Chemical Characteristics of Lipoplexes Influence Cell Uptake Mechanisms and Transfection Efficacy
- Cyclodextrin-based pharmaceutics: past, present and future
- Cyclodextrin gene vectors: cell trafficking and the influence of lipophilic chain length
Cited by
- Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells
- Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution.
- Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design
- Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations.
- Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system.
- Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in vitro analysis.
- Delivering RNAi therapeutics with non-viral technology: a promising strategy for prostate cancer?
- Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery
- In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery
- A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor.
- Recent advances in cyclodextrin delivery techniques
- Nanoassemblies based on non-ionic amphiphilic cyclodextrin hosting Zn(II)-phthalocyanine and docetaxel: Design, physicochemical properties and intracellular effects.
- Nanoparticles and the Blood-Brain Barrier: Advancing from In-Vitro Models Towards Therapeutic Significance
- Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo.
- Nanoparticle-mediated siRNA delivery assessed in a 3D co-culture model simulating prostate cancer bone metastasis.
- Mesoporous self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances.
- Potential therapeutic application of dendrimer/cyclodextrin conjugates with targeting ligands as advanced carriers for gene and oligonucleotide drugs.
- Molecular nanoparticle-based gene delivery systems
- Cancer nanotheranostics: A review of the role of conjugated ligands for overexpressed receptors
- Folate-targeted amphiphilic cyclodextrin nanoparticles incorporating a fusogenic peptide deliver therapeutic siRNA and inhibit the invasive capacity of 3D prostate cancer tumours.
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