Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles.
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Summary
The physicochemical and biological characterization of cyclodextrin-containing polycations (CDP) and their nanoparticles formed with nucleic acids including plasmid DNA (pDNA) and small interfering RNA (siRNA) are described and insights can be applied to the design of targeted nucleic acid delivery vehicles in general.
- Type
- article
- Published
- 2007-02-28
- Cited by
- 268
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W1970238359
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39248691
Keywords
Chemistry, Nucleic acid, Biophysics, Small interfering RNA, Ethylene glycol
References
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- Targeting of Synthetic Gene Delivery Systems
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- Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery
- Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformability.
- Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma.
- Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
- PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles.
- Imidazole groups on a linear, cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes.
- Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
- PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
- RNAi-mediated gene silencing in non-human primates
- Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers.
- Osmotic properties of poly(ethylene glycols): quantitative features of brush and bulk scaling laws.
- Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
- The silent treatment: siRNAs as small molecule drugs
Cited by
- Efficient Protection and Transfection of Small Interfering RNA by Cationic Shell-Crosslinked Knedel-Like Nanoparticles
- Cell-specific siRNA delivery by peptides and antibodies.
- Therapeutic targeting in the silent era: advances in non-viral siRNA delivery.
- Biomaterials in siRNA Delivery: A Comprehensive Review
- Functionalized bioengineered spider silk spheres improve nuclease resistance and activity of oligonucleotide therapeutics providing a strategy for cancer treatment
- Nanoparticle therapeutics: FDA approval, clinical trials, regulatory pathways, and case study.
- Nanoparticle based strategies for the treatment of Glioblastoma
- Effect of siRNA pre-Exposure on Subsequent Response to siRNA Therapy
- Effects of siRNA-squalene nanoparticles on RET/PTCs junction oncogenes in papillary thyroid carcinoma : from molecular and cellular studies to preclinical investigations
- Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA
- Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
- Study of Mesoporous Silica Nanoparticles' (MSNs) intracellular trafficking and their application as drug delivery vehicles
- Targeted delivery of anti-cancer drugs by MS2 virus-like particles
- Oncogene dependency and the potential of targeted RNAi-based anti-cancer therapy.
- Delivery of small nucleic acids by conjugation to carbohydrates and lipids as novel research and therapeutic tools
- Combination of sequence‐defined oligoaminoamides with transferrin‐polycation conjugates for receptor‐targeted gene delivery
- Targeting Tumors and the Kidney with siRNA Nanoparticles and Evaluation of Extracellular MicroRNA-based Methodologies to Track Their Activity
- Host-Guest-Mediated DNA Templation of Polycationic Supramolecules for Hierarchical Nanocondensation and the Delivery of Gene Material.
- Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice.
- Size-tunable supramolecular nanoparticles mediated by ternary cucurbit[8]uril host-guest interactions.
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