Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery.
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Summary
This is the first time that a modified β-cyclodextrin vector has been used as a safe and efficacious vector for siRNA delivery into neuronal cells.
- Type
- article
- Published
- 2012-10-17
- Cited by
- 68
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W23077718
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36809503
Keywords
History
References
- Highly Efficient Small Interfering RNA Delivery to Primary Mammalian Neurons Induces MicroRNA-Like Effects before mRNA Degradation
- Therapeutic targeting in the silent era: advances in non-viral siRNA delivery.
- Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins
- Viral vectors for gene delivery to the nervous system
- Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
- Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles.
- The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells
- A new potent secondary amphipathic cell-penetrating peptide for siRNA delivery into mammalian cells.
- A novel method for RNA interference in neurons using enhanced green fluorescent protein (EGFP)-transgenic rats.
- Adipokine Gene Expression in a Novel Hypothalamic Neuronal Cell Line: Resistin-Dependent Regulation of Fasting-Induced Adipose Factor and SOCS-3
- A click chemistry route to 2-functionalised PEGylated and cationic β-cyclodextrins: co-formulation opportunities for siRNA delivery.
- Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain.
- BACE1 Suppression by RNA Interference in Primary Cortical Neurons*
- RNAi functions in cultured mammalian neurons
- Valproic Acid and CEBPα-Mediated Regulation of Adipokine Gene Expression in Hypothalamic Neurons and 3T3-L1 Adipocytes
- Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles.
- Cationic cyclodextrin amphiphiles as gene delivery vectors
- Endogenous Amyloid-β is Necessary for Hippocampal Synaptic Plasticity and Memory
- Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrPC on Neuronal Cells and PrPRES in Infected Cell Cultures
- TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting
Cited by
- Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells
- The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics.
- Cyclodextrin mediated delivery of NF-κB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro
- A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy.
- Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution.
- Host-Guest-Mediated DNA Templation of Polycationic Supramolecules for Hierarchical Nanocondensation and the Delivery of Gene Material.
- Biomaterial approaches to gene therapies for neurodegenerative disorders of the CNS.
- Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system.
- Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications.
- Gastrointestinal gene delivery by cyclodextrins--in vitro quantification of extracellular barriers.
- Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations.
- Self-assembling modified β-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease.
- GDNF gene delivery via a 2-(dimethylamino)ethyl methacrylate based cyclized knot polymer for neuronal cell applications.
- Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system.
- Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in vitro analysis.
- Delivering RNAi therapeutics with non-viral technology: a promising strategy for prostate cancer?
- 'Click' synthesized sterol-based cationic lipids as gene carriers, and the effect of skeletons and headgroups on gene delivery.
- Targeting, Endocytosis, and Lysosomal Delivery of Active Enzymes to Model Human Neurons by ICAM-1-Targeted Nanocarriers
- Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery
- In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery
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