Nanoparticles and the Blood-Brain Barrier: Advancing from In-Vitro Models Towards Therapeutic Significance
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Summary
This review provides a comprehensive description of the design and formulation of these nanoparticles including the rationale behind individual approaches and the ability of currently available in-vitro BBB models to accurately predict the in- vivo performance of targeted nanoparticles is critically assessed.
- Type
- review
- Published
- 2015-04-01
- Cited by
- 121
- References
- 222
- OpenAlex
- https://openalex.org/W2464874208
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11447079
Keywords
Blood–brain barrier, In vivo, In vitro, Central nervous system, Pharmacology
References
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- Interactions between antidepressants and P‐glycoprotein at the blood–brain barrier: clinical significance of in vitro and in vivo findings
- Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins.
- Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles
- In Vivo and in Vitro Assessment of Baseline Blood-Brain Barrier Parameters in the Presence of Novel Nanoparticles
- Animal models got you puzzled?: think pig
- Tight junctions of the blood-brain barrier: development, composition and regulation.
- Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies.
- Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution.
- A dual-targeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas.
- Transcytosis of CRM197-grafted polybutylcyanoacrylate nanoparticles for delivering zidovudine across human brain-microvascular endothelial cells.
- Analysis of Biotinylated Generation 4 Poly(amidoamine) (PAMAM) Dendrimer Distribution in the Rat Brain and Toxicity in a Cellular Model of the Blood-Brain Barrier
Cited by
- Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics
- HPLC-UV method development and validation for the quantification of ropinirole in new PLGA multiparticulate systems: Microspheres and nanoparticles.
- Therapeutic benefits of nanoparticles in stroke
- Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells.
- RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies.
- Enzyme replacement and gene therapy for mucopolysaccharidoses: current progress and future directions
- Three Valuable Peptides from Bee and Wasp Venoms for Therapeutic and Biotechnological Use: Melittin, Apamin and Mastoparan
- Effect of PLGA NP size on efficiency to target traumatic brain injury.
- Functionalized magnetic nanochains with enhanced MR imaging: A novel nanosystem for targeting and inhibition of early glioma.
- Polyglycerol-Based Copper Chelators for the Transport and Release of Copper Ions in Biological Environments.
- Cellular and molecular effects of metal oxide nanoparticles on human neuronal cells
- Blood-brain barrier co-culture models to study nanoparticle penetration: focus on co-culture systems
- Nano carriers for drug transport across the blood–brain barrier
- Powering up the molecular therapy of RNA interference by novel nanoparticles.
- Physicochemical properties of engineered nanomaterials that influence their nervous system distribution and effects.
- In vitro blood-brain barrier models for drug research: state-of-the-art and new perspectives on reconstituting these models on artificial basement membrane platforms.
- Exposure, tissue biodistribution, and biotransformation of nanosilver
- In vitro screening of nanomedicines through the blood brain barrier: A critical review.
- Artemisinin and Its Derivatives as a Repurposing Anticancer Agent: What Else Do We Need to Do?
- Effect of peptide functionalization on nanoparticle transport across brain endothelium in a microfluidic chip
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