Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
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Summary
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.
- Type
- article
- Published
- 1984-05-31
- Cited by
- 2,421
- References
- 54
- OpenAlex
- https://openalex.org/W1995337883
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4261582
Keywords
A431 cells, Epidermal growth factor, Complementary DNA, Biology, Epidermoid carcinoma
References
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- Effect of chromosomal position on amplification of transfected genes in animal cells
Cited by
- Signal transmission by epidermal growth factor receptor: coincidence of activation and dimerization.
- Functional adaptations of transbilayer proteins.
- Activation of cancer cell proteases and cytotoxicity by EGF and PDGF growth factors.
- Immune Interferon Receptor: Chemical and Enzymatic Sensitivity
- EGF receptor-associated DNA-nicking activity is due to a Mr-100,000 dissociable protein
- Epidermal growth factor regulates the expression of its own receptor.
- Synthesis of epidermal growth factor (EGF) receptor in vitro using SP6 RNA polymerase-transcribed template mRNA.
- A new acute transforming feline retrovirus with fms homology specifies a C-terminally truncated version of the c-fms protein that is different from SM-feline sarcoma virus v-fms protein
- Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.
- A complementary DNA clone for a macrophage-lymphocyte Fc receptor
- Biochemical characterization of cellular hormone receptors.
- Membrane‐bound LERK2 ligand can signal through three different Eph‐related receptor tyrosine kinases.
- Acidic fgf and egf are involved in the autocrine growth stimulation of a human nasopharyngeal carcinoma cell line and sub‐line cells
- A Conformation-specific Anti-peptide Antibody to the β-Type Platelet-derived Growth Factor Receptor Also Recognizes the Activated Epidermal Growth Factor Receptor (*)
- Redistribution of epidermal growth factor receptor as a function of cell density, cell-cell adhesion and calcium in human (A-431) cells.
- Effects of retinol on the temporal expression of transforming growth factor-alpha mRNA in the embryonic mouse mandible.
- Regulation of epidermal growth factor receptor activity by crotoxin, a snake venom phospholipase A2 toxin. A novel growth inhibitory mechanism.
- High expression of the fee gene product in murine testicular germ cells and erythroblasts
- Lack of prognostic relevance of alterations in the epidermal growth factor receptor-transforming growth factor-alpha pathway in human astrocytic gliomas.
- Ontogeny of EGF receptors in the human gut.
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