Epidermal growth factor stimulates the growth of A431 tumors in athymic mice.
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Summary
The data suggest that the mechanism(s) involved in the inhibition of A431 cell growth by EGF in vitro does not function in vivo and the physiologically significant effect of E GF in vivo is growth promotion.
- Type
- article
- Published
- 1985-09-15
- Cited by
- 33
- References
- 19
- OpenAlex
- https://openalex.org/W1967509742
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23471707
Keywords
Epidermal growth factor, In vivo, A431 cells, Endocrinology, Epidermoid carcinoma
References
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- Functional differentiation in mouse mammary gland epithelium is attained through DNA synthesis, inconsequent of mitosis.
- Isolation, characterization, and regulation of the prolactin receptor.
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- Analysis of morphology and receptor metabolism in clonal variant A431 cells with differing growth responses to epidermal growth factor
- Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431.
- Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor.
- Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.
- Epidermal growth factor inhibits growth of A431 human epidermoid carcinoma in serum-free cell culture
- Epidermal growth factor: effects of androgens and adrenergic agents.
- High affinity epidermal growth factor receptors on the surface of A431 cells have restricted lateral diffusion.
- Epidermal growth factor measurements in mouse plasma: method, ontogeny, and sex difference.
- Epidermal growth factor
Cited by
- The epidermal growth factor receptor and its ligands.
- Breast Cancer: Cellular and Molecular Biology
- Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts.
- Ras-independent oncogenic transformation by an EGF-receptor mutant.
- Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line.
- Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids.
- The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study
- Quantitative differences in the effects of mouse and human epidermal growth factors on A431 human tumor cells.
- Effects of antiepidermal growth factor receptor antibody 528 on the proliferation and differentiation of head and neck cancer.
- Local effects of EGF, α‐TGF, and EGF‐like growth factors on lobuloalveolar development of the mouse mammary gland in vivo
- Effect of endogenous and exogenous EGF on the growth of EGF receptor-hyperproducing human squamous cell carcinoma implanted in nude mice.
- Protein-tyrosine Phosphatase α Regulates Src Family Kinases and Alters Cell-Substratum Adhesion*
- Epidermal growth factor stimulates the anchorage-independent growth of human squamous cell carcinomas overexpressing its receptors.
- Stimulation by EGF of the growth of EGF receptor‐hyperproducing tumor cells in athymic mice
- Epidermal growth factor-related peptides and their receptors in human malignancies.
- Characterization of a monoclonal antibody against human prolactin receptors
- Epidermal Growth Factor and Its Receptors in Human Pancreatic Carcinoma
- Signaling and drug sensitivity
- Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition
- Adaptation of EGF receptor signal transduction to three‐dimensional culture conditions: Changes in surface receptor expression and protein tyrosine phosphorylation
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