The molecular heterogeneity of protein kinase C and its implications for cellular regulation
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Summary
Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics, and probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.
- Type
- review
- Published
- 1988-08-01
- Cited by
- 3,922
- References
- 58
- OpenAlex
- https://openalex.org/W1993282564
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4336110
Keywords
Kinase, Intracellular, Biology, Cell biology, Protein kinase A
References
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- Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid.
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- Ca2+-independent activation of protease-activated kinase II by phospholipids/diolein and comparison with the Ca2+/phospholipid-dependent protein kinase.
- The structure, expression, and properties of additional members of the protein kinase C family.
- A cDNA encoding protein kinase C identifies two species of mRNA in brain and GH3 cells.
- A monoclonal antibody recognising the site of limited proteolysis of protein kinase C. Inhibition of down-regulation in vivo.
- Postnatal development of a brain-specific subspecies of protein kinase C in rat
- Distribution of protein kinase C-like immunoreactive neurons in rat brain
- Phorbol-ester-induced alterations of free calcium ion transients in single rat hepatocytes.
- Studies and perspectives of protein kinase C.
- Differential expression of multiple protein kinase C subspecies in rat central nervous tissue.
- Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation.
- Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.
Cited by
- Protein kinases and phosphatase inhibitors mediating long-term desensitization of glutamate receptors in cerebellar Purkinje cells.
- Phosphoinositide and calcium signalling responses in smooth muscle cells: comparison between lipoproteins, Ang II, and PDGF.
- PKC epsilon is involved in granulocyte-macrophage colony-stimulating factor signal transduction: evidence from microphysiometry and antisense oligonucleotide experiments.
- The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta.
- Phospholipase C-induced monocytic differentiation in a human monocytic leukemia cell line THP-1.
- Signal transduction mechanisms involved in carbachol-induced aldosterone secretion from bovine adrenal glomerulosa cells.
- Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration.
- The structural mimicry of membrane sterols by tamoxifen: evidence from cholesterol coefficients and molecular-modelling for its action as a membrane anti-oxidant and an anti-cancer agent.
- Adrenergic receptor research: recent developments.
- Long‐Term Activation of Protein Kinase C by Nicotine in Bovine Adrenal Chromaffin Cells
- Cellular distribution of gastric chief cell protein kinase C activity: Differential effects of diacylglycerol, phorbol esters, carbachol, and cholecystokinin
- Protein kinases associated with proliferation and differentiation in murine erythroleukaemic cells.
- The modulation of growth by HMBA in PKC overproducing HT29 colon cancer cells.
- Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism.
- Contrasting effects of sn-1,2-dioctanoyl glycerol as compared to other protein kinase C activators in adrenal glomerulosa cells.
- Second messengers derived from inositol lipids
- Überexpression von Proteinkinase-C-Isoenzymen in menschlichen Tumorzellinien
- Increased PKA and PKC activities accompany neuronal differentiation of NT2/D1 cells
- Induction of differentiation in v-Ha-ras-transformed MDCK cells by prostaglandin E2 and 8-bromo-cyclic AMP is associated with a decrease in steady-state level of inositol 1,4,5-trisphosphate
- Growth hormone stimulates the formation of sn-1,2-diacylglycerol in rat hepatocytes.
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