The structural mimicry of membrane sterols by tamoxifen: evidence from cholesterol coefficients and molecular-modelling for its action as a membrane anti-oxidant and an anti-cancer agent.

Keywords

Geology, Pennsylvanian, Paleontology, Structural basin, Lithology

References

• Protection by glutathione against one component of the bimodal inhibition of growth by tamoxifen in Saccharomyces cerevisiae.滋 高見澤, 力 津川, 栄治 西島 — 1990
• Mechanism of inhibition of lipid peroxidation by tamoxifen and 4‐hydroxytamoxifen introduced into liposomesHelen Wiseman, Mark Cannon, H. R. V. Arnstein — 1990
• Estrogen receptor-mediated and cytotoxic effects of the antiestrogens tamoxifen and 4-hydroxytamoxifen.Carol M. Taylor, Beatrix Blanchard, David T. Zava — 1984
• Ca2(+)-dependent binding of tamoxifen to calmodulin isolated from bovine brain.María Celeste Lopes, M.G.P. Vale, A.P. Carvalho — 1990
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• Multiple mechanisms of protein kinase C inhibition by triphenylacrylonitrile antiestrogensEric Bignon, Michel Pons, Jacques Gilbert — 1990
• Identification of products formed during UV irradiation of tamoxifen and their use for fluorescence detection in high-performance liquid chromatography.Jaroslav Šalamoun, Mirek Macka, Miloš Nechvátal — 1990
• The antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidationHelen Wiseman, Miranda J. Laughton, H. R. V. Arnstein — 1990
• Action of antiestrogens on the (Ca2+ + Mg2+)-ATPase and Na+/Ca2+ exchange of brain cortex membranes.João O. Malva, María Celeste Lopes, M.G.P. Vale — 1990
• A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer.T.J. Powles, J Hardy, S. Ashley — 1989
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• Membrane fluidity affects tumor‐cell motility, invasion and lung‐colonizing potentialGiulia Taraboletti, Lianna Perin, Barbara Bottazzi — 1989
• Tamoxifen as a potential preventive agent in healthy postmenopausal women.R. L. Prentice — 1990
• The antioxidant action of ketoconazole and related azoles: comparison with tamoxifen and cholesterol.Helen Wiseman, Cheryl Smith, H. R. V. Arnstein — 1991
• Variation of the inhibition of calmodulin dependent cyclic AMP phosphodiesterase amongst analogues of tamoxifen; correlations with cytotoxicity.Martin Rowlands, Iris B. Parr, Raymond McCague — 1990
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• Tamoxifen metabolism: pharmacokinetic and in vitro study.M C Etienne, G. Milano, J-L Fischel — 1989
• Analysis of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen levels in cytosol and KCl-nuclear extracts of breast tumours from tamoxifen treated patients by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM).Carol Murphy, Theodore Fotsis, P Pantzar — 1987
• A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomasPaul Basset, Jean‐Pierre Bellocq, C Wolf — 1990
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Cited by

• Tamoxifen Increases Membrane Fluidity at High ConcentrationsFeride Severcan, Nadide Kazancı, Faruk Zorlu — 2000
• Tamoxifen and related compounds decrease membrane fluidity in liposomesHelen Wiseman, Peter J. Quinn, Barry Halliwell — 1993
• Environmental Estrogen-Like Chemicals and Hydroxyl Radicals Induced by MPTP in the Striatum: A ReviewToshia Obata — 2002
• Tamoxifen inhibits lipid peroxidation in cardiac microsomes. Comparison with liver microsomes and potential relevance to the cardiovascular benefits associated with cancer prevention and treatment by tamoxifen.Helen Wiseman, Michael Cannon, H. R. V. Arnstein — 1993
• Tamoxifen‐treated breast carcinoma patients and the risk of acute myocardial infarction and newly‐diagnosed anginaBrian D. Bradbury, Timothy L. Lash, James A. Kaye — 2005
• Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances.Helen Wiseman — 1994
• Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity.José B.A. Custódio, Teresa C.P. Dinis, Leonor M. Almeida — 1994
• Dopamine efflux by MPTP and hydroxyl radical generationToshio Obata — 2002
• Tamoxifen decreases drug efflux from liposomes: Relevance to its ability to reverse multidrug resistance in cancer cells?Reem Kayyali, Christopher Marriott, Helen Wiseman — 1994
• Protective action of putrescine against rat liver injury.Sumiko Nagoshi, Yoshihiro Ohta, Akihiro Matsui — 1994
• Treatment with tamoxifen reduces hypoxic-ischemic brain injury in neonatal rats.Yangzheng Feng, Jonathan D. Fratkins, Michael H. LeBlanc — 2004
• Inhibition of estrone sulfatase and 17β-hydroxysteroid dehydrogenase by antiestrogensSteven J. Santner, Richard J. Santen — 1993
• Vitamin D is a membrane antioxidant Ability to inhibit iron‐dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer actionHelen Wiseman — 1993
• Enhancement by tamoxifen of the membrane antioxidant action of the yeast membrane sterol ergosterol: relevance to the antiyeast and anticancer action of tamoxifen.Helen Wiseman, Michael Cannon, H. R. V. Arnstein — 1993
• Droloxifene (3-hydroxytamoxifen) has membrane antioxidant ability: potential relevance to its mechanism of therapeutic action in breast cancer.Helen Wiseman, Cheryl Smith, Barry Halliwell — 1992
• Antioxidant properties of the triphenylethylene antiestrogen drug toremifeneMarkku Ahotupa, Eero Mäntylä, Lauri Kangas — 1997
• Tamoxifen and related compounds protect against lipid peroxidation in isolated nuclei: relevance to the potential anticarcinogenic benefits of breast cancer prevention and therapy with tamoxifen?Helen Wiseman, Barry Halliwell — 1994
• Nitric oxide and MPP+-induced hydroxyl radical generationToshio Obata — 2006
• Concentration Dependent Different Action of Tamoxifen on Membrane FluidityNadide Kazancı, Feride Severcan — 2007
• Aging, Menopause, and Free RadicalsDawn C. Schwenke — 1998

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