Phospholipase C-induced monocytic differentiation in a human monocytic leukemia cell line THP-1.
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Summary
The PLC-induced monocytic differentiation in THP-1 cells was inhibited by staurosporine, a potent PK-C inhibitor, further suggesting that direct activation of thePK-C is one of the metabolic events essential for monocytical differentiation.
- Type
- article
- Published
- 1992-07-01
- Cited by
- 3
- References
- 19
- OpenAlex
- https://openalex.org/W2119925358
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33010892
Keywords
THP1 cell line, Monocytic leukemia, Acute monocytic leukemia, Cell culture, Leukemia
References
- Expression of c-fos, c-myb, and c-myc in human monocytes: correlation with monocytic differentiation.
- Phospholipase C activates protein kinase C and induces monocytic differentiation of HL-60 cells.
- Changes in c-myc, c-fms, and N-ras proto-oncogene expression associated with retinoic acid-induced monocytic differentiation of human leukemia HL60/MRI cells.
- Effects of recombinant human colony stimulating factors (CSF) (granulocyte-macrophage CSF, granulocyte CSF, and CSF-1) on human monocyte/macrophage differentiation.
- Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.
- Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
- Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.
- The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1.
- Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome.
- Phorbol diester receptor copurifies with protein kinase C.
- Expression of the c-fms proto-oncogene during human monocytic differentiation
- The molecular heterogeneity of protein kinase C and its implications for cellular regulation
- Inhibition of TPA-induced monocytic differentiation in THP-1 human monocytic leukemic cells by staurosporine, a potent protein kinase C inhibitor.
- Synergism between hemopoietic growth factors (HGFs) detected by their effects on cells bearing receptors for a lineage specific HGF: Assay of hemopoietin‐1
- Delineation of receptor‐mediated colony‐stimulating factor (CSF‐1) utilization and cell production by precursors of mononuclear phagocytic series at various stages of differentiation
- Molecular Cloning: A Laboratory Manual
- Biological response modifiers released by a mezerein-treated human monocytic leukemia cell line, THP-1.
- Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells.
Cited by
- Vitamin D3-driven signals for myeloid cell differentiation - Implications for differentiation therapy
- A cardiotonic steroid bufalin-induced differentiation of THP-1 cells. Involvement of Na+, K(+)-ATPase inhibition in the early changes in proto-oncogene expression.
- Profile of tRNA-derived short non-coding RNAs during monocyte differentiation and their role in macrophage survival
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