IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
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Summary
Results indicate that TNF-α induces insulin resistance through an unexpected action of IRS-1 to attenuate insulin receptor signaling.
- Type
- article
- Published
- 1996-02-02
- Cited by
- 2,759
- References
- 24
- OpenAlex
- https://openalex.org/W1988870963
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2616242
Keywords
Insulin resistance, Insulin receptor, Internal medicine, Endocrinology, Insulin receptor substrate
References
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- Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system
- Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
- Role of IRS-2 in insulin and cytokine signalling
- IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
- Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
- Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
- Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.
- Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
- The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.
- Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.
- Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
- Insulin resistance--mechanisms, syndromes, and implications.
- Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions.
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- β1-adrenergic receptor stimulation by agonist Compound 49b restores insulin receptor signal transduction in vivo
- Effects of Resistance Training on Insulin Sensitivity and Markers of Inflammation in Rheumatoid Arthritis Patients Treated with Remicade
- Pathophysiology of nonalcoholic steatohepatitis.
- Insulin Receptor Substrate-1 Phosphorylation and Phosphatidylinositol 3-Kinase Activity in Skeletal Muscle From NIDDM Subjects After In Vivo Insulin Stimulation
- Expression of plasminogen activator inhibitor-1 in human adipose tissue: a role for TNF-alpha?
- The role of cytokines in cancer cachexia
- Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness
- The role of fat depletion in the biological benefits of caloric restriction.
- The G-308A variant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distribution
- The effects of resistance training on individuals with clusters of metabolic risk factors : focus on functional capacities, clinical outcomes and quality of life
- A family history of Type 2 diabetes is associated with increased plasma levels of C‐reactive protein in non‐smoking healthy adult women
- Cell-permeable ceramides increase basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes
- [Contribution of diabetic research to versatile strategies for the treatment of diabetes mellitus].
- T-CELL AND NEURONAL APOPTOSIS IN HIV INFECTION: IMPLICATIONS FOR THERAPEUTIC INTERVENTION
- Hepatocytes: critical for glucose homeostasis.
- The anti-inflammatory effect of exercise.
- Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake
- Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats
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