Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

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Summary

Serine/threonine phosphorylation of IRS 1 induced by okadaic acid reduces the ability of the insulin receptor to phosphorylate IRS 1 and to dock one of its interacting molecules, i.e. PI 3-kinase.

Type
article
Published
1994-02-25
Cited by
291
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0
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Open access

Keywords

Insulin receptor, Okadaic acid, Phosphorylation, Tyrosine phosphorylation, Insulin receptor substrate

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