Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.
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Summary
It is demonstrated that E2F-1 and DP-1 association is required for stable interaction with pRB in vivo and that trans-activation by E2f-1/DP-1 heterodimers is inhibited by pRB.
- Type
- article
- Published
- 1993-10-01
- Cited by
- 507
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W2061665609
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21864147
Keywords
E2F, Biology, Transcription factor, Retinoblastoma protein, Transcription (linguistics)
References
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- Antibodies: A Laboratory Manual
- Cell cycle regulation of the human cdc2 gene.
- Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides
- Association of adenovirus early-region 1A proteins with cellular polypeptides
- The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding
- Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.
- Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo
- Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F
- Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
- Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes
- Transcriptional repression by the Rb-related protein p107.
- A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells.
- Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.
- Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
- Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation.
- Transcriptional regulation by dimerization: two sides to an incestuous relationship.
Cited by
- Development of an shRNA screen to identify mediators of cellular senescence in human breast epithelial cells
- Chromosomes and expression mechanisms
- Anchorage-Independent Transcription of the Cyclin A Gene Induced by the E7 Oncoprotein of Human Papillomavirus Type 16
- Transcription factor E2F‐1 acts as a growth‐promoting factor and is associated with adverse prognosis in non‐small cell lung carcinomas
- Identification of Potential Gene Interactions in Heart Failure Caused by Idiopathic Dilated Cardiomyopathy
- Cell cycle control and its modulation in HPV infected cells
- Loss of E2F3a Function Mitigates the Developmental Defects Associated with Rb-deficiency
- Unbound E2F modulates TGF-β1-induced apoptosis in HuH-7 cells
- Myc and the cell cycle.
- Regulatory interactions among E2Fs and cell cycle control proteins.
- Transcription Factor Effector Domains
- Growth regulation by the E2F and DP transcription factor families.
- Dictyostelium cell-fate bias is regulated antagonistically by the Retinoblastoma orthologue RblA and the cyclin-dependent kinase Cdk1
- Regulation of G1 phase.
- Introduction to the E2F family: protein structure and gene regulation.
- Cell Cycle Control
- Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma.
- The role of the transcription factor DP in apoptosis
- The structure, function, and regulation of papillomaviral genes in infection and cervical cancer.
- Régulation de la différenciation du muscle strié squelettique par la voie let-7 – E2F5
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