Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity
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Summary
Testosterone replacement in older hypogonadal men alters the protein composition of HDL but does not significantly change serum HDL-mediated cholesterol efflux, and these effects appear independent of testosterone conversion to dihydrotestosterone.
- Type
- article
- Published
- 2012-07-01
- Cited by
- 38
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W1984013074
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25591454
Keywords
Testosterone (patch), Efflux, Cholesterol, Endocrinology, Internal medicine
References
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- PON-dering differences in HDL function in coronary artery disease.
- Apolipoprotein C-I binds more strongly to phospholipid/triolein/water than triolein/water interfaces: a possible model for inhibiting cholesterol ester transfer protein activity and triacylglycerol-rich lipoprotein uptake
- High density lipoprotein: it’s not just about lipid transport anymore
- HDL suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide
- HDL Composition Regulates Displacement of Cell Surface-Bound Hepatic Lipase
- Protection Against Atherogenesis in Mice Mediated by Human Apolipoprotein A-IV
- Myeloperoxidase: An oxidative pathway for generating dysfunctional HDL
- Post-transcriptional regulation of apoC-I synthesis and secretion in human HepG2 cells.
- Acute Sex Steroid Withdrawal Increases Cholesterol Efflux Capacity and HDL-Associated Clusterin in Men
- Lipoproteomics II: Mapping of proteins in high‐density lipoprotein using two‐dimensional gel electrophoresis and mass spectrometry
- HDL and cardiovascular-disease risk--time for a new approach?
- The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis This work was supported by P01-HL22633 from the NHLBI. Published, JLR Papers in Press, December 8, 2008.
- Effects of torcetrapib in patients at high risk for coronary events.
- HDL in humans with cardiovascular disease exhibits a proteomic signature
- Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis
- Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study.
- Sequential estrogen-progestin replacement therapy in healthy postmenopausal women: effects on cholesterol efflux capacity and key proteins regulating high-density lipoprotein levels.
- Androgens and coronary artery disease.
Cited by
- High-density lipoproteins: a consensus statement from the National Lipid Association.
- HDL and cholesterol: life after the divorce?1
- Low testosterone concentration and atherosclerotic disease markers in male patients with type 2 diabetes.
- Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond1
- Functionally Defective High-Density Lipoprotein and Paraoxonase: A Couple for Endothelial Dysfunction in Atherosclerosis
- Testosterone, HDL and cardiovascular risk in men: the jury is still out
- Comparative safety evaluation of selective androgen receptor modulators and anabolic androgenic steroids
- An update on testosterone, HDL and cardiovascular risk in men
- Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long-term registry study
- The effect of androgens on lipids
- Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial.
- Benefits and Harms of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review and Network Meta-analysis
- Gender-related impact on outcomes of high density lipoprotein in acute ST-elevation myocardial infarction.
- Effects of Fermented Dandelion (Taraxacum coreanum) Extract on Male Climacteric Syndrome
- The cholesterol lowering effects of Eurycoma longifolia Jack (Tongkat Ali) root extract in male rats
- Cardiovascular Health, Erectile Dysfunction, and Testosterone Replacement: Controversies and Correlations.
- Sex Steroids Mediate Discrete Effects on HDL Cholesterol Efflux Capacity and Particle Concentration in Healthy Men
- The effect of testosterone on factors associated with diabetes, atherosclerosis and obesity.
- Diminished cholesterol efflux mediated by HDL and coronary artery disease in young male anabolic androgenic steroid users.
- High-Density Lipoprotein Function Is Reduced in Patients Affected by Genetic or Idiopathic Hypogonadism.
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