Modifying Apolipoprotein A-I by Malondialdehyde, but Not by an Array of Other Reactive Carbonyls, Blocks Cholesterol Efflux by the ABCA1 Pathway*
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Summary
Observations indicate that MDA damages apoA-I by a pathway that generates lysine adducts at specific sites on the protein, which may facilitate the formation of macrophage foam cells by impairing cholesterol efflux by the ABCA1 pathway.
- Type
- article
- Published
- 2010-04-08
- Cited by
- 135
- References
- 70
- Access
- Open access
- OpenAlex
- https://openalex.org/W1505364624
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19967626
Keywords
Chemistry, Biochemistry, ABCA1, Lipid peroxidation, PON1
References
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- The Structure of Apolipoprotein A-I in High Density Lipoproteins*
- ARTERIO-SCLEROSIS
- Electron Paramagnetic Resonance Spectroscopy of Site-directed Spin Labels Reveals the Structural Heterogeneity in the N-terminal Domain of ApoA-I in Solution*
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- Myeloperoxidase: An oxidative pathway for generating dysfunctional HDL
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- The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation.
- Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease.
- Mechanism of Protein Modification by Glyoxal and Glycolaldehyde, Reactive Intermediates of the Maillard Reaction (*)
- Deletion of the C-terminal domain of apolipoprotein A-I impairs cell surface binding and lipid efflux in macrophage.
Cited by
- Signal transduction pathways provide opportunities to enhance HDL and apoAI-dependent reverse cholesterol transport.
- Alteration of HDL functionality and PON1 activities in acute coronary syndrome patients.
- Effect of chronic kidney disease on macrophage cholesterol efflux.
- Residual Cardiovascular Risk in Chronic Kidney Disease: Role of High-density Lipoprotein
- 4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product
- High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.
- PON-dering differences in HDL function in coronary artery disease.
- The complexity of HDL.
- Redox proteomics: chemical principles, methodological approaches and biological/biomedical promises.
- Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions
- Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity
- High-Density Lipoprotein: Is the Good Cholesterol Turning Bad?
- Metabolic and functional relevance of HDL subspecies
- Structure of Apolipoprotein A-I N Terminus on Nascent High Density Lipoproteins*
- A rational approach to prevent postprandial modification of LDL by dietary polyphenols
- Protein carbamylation renders high-density lipoprotein dysfunctional
- Oxidized-phospholipids in reconstituted high density lipoprotein particles affect structure and function of recombinant paraoxonase 1.
- HDL-apoA-I Exchange: Rapid Detection and Association with Atherosclerosis
- Myeloperoxidase Targets Apolipoprotein A-I, the Major High Density Lipoprotein Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions*
- CETP Inhibitors: Will They Live up to Their Promise?
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