Cellular senescence revisited: a review.
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Summary
The field of cellular senescence (cytogerontology) is reviewed, and the view that the life span of normal diploid cells in culture is limited, is under genetic control, and is capable of being modified is included.
- Type
- review
- Published
- 1987-03-01
- Cited by
- 171
- References
- 490
- OpenAlex
- https://openalex.org/W1965076280
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10259652
Keywords
Senescence, Biology, Embryonic stem cell, Cellular model, Context (archaeology)
References
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- Senescence and vascular disease.
- Posttranslational modifications of enzymes.
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- The effect of hydrocortisone on DNA synthesis and cell division during aging in vitro.
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- Time-lapse cinemicrophotographic studies of cell division patterns of human diploid fibroblasts (WI-38) during their in vitro lifespan.
- Multinucleation and polyploidization of aging human cells in culture.
- Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.
- The keratinocyte as differentiated cell type.
- Pathological implications of cell aging in vitro.
Cited by
- Age-related alterations in collagen and total protein metabolism determined in cultured rat dermal fibroblasts: age-related trends parallel those observed in rat skin in vivo.
- Replicative Senescence and Cell Immortality: The Role of Telomeres and Telomerase
- Replicative Potential and Telomere Length in Human Skeletal Muscle: Implications for Satellite Cell-Mediated Gene Therapy
- Optimization of human corneal endothelial cell culture: density dependency of successful cultures in vitro
- Analysis of tumor suppressor gene-induced senescence.
- Role of endogenous proteins as negative growth modulators during in vitro cellular aging of human diploid fibroblasts.
- Immortalization and transformation of human cells.
- Germ Cell Development, Division, Disruption and Death
- Molecular Biology In Cellular Pathology
- Role of telomere dysfunction in genetic intratumor diversity.
- Regulation of cellular senescence by p53.
- Human ageing and telomeres.
- Telomere dysfunction, genome instability and cancer.
- The Outer Limits: Telomere Maintenance by TRF2 and G-Quadruplex DNA Structures
- Soft-tissue aging and musculoskeletal function.
- Bone marrow-derived cells: the influence of aging and cellular senescence.
- DNA replication licensing and human cell proliferation.
- Senescence represses the nuclear localization of the serum response factor and differentiation regulates its nuclear localization with lineage specificity.
- Psoralen photoactivation promotes morphological and functional changes in fibroblasts in vitro reminiscent of cellular senescence.
- The Effects of Aging, Antiinflammatory Drugs, and Ultrasound on the In Vitro Response of Tendon Tissue
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