An expanding role for mTOR in cancer.
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Summary
MTOR signaling is re-evaluate, suggesting a more central role for mTOR in cancers with defective PtdIns3K-PTEN signaling and conceptually discuss these implications in the context of drug discovery.
- Type
- review
- Published
- 2005-08-01
- Cited by
- 559
- References
- 114
- OpenAlex
- https://openalex.org/W2005496215
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6279718
Keywords
PTEN, Tensin, PI3K/AKT/mTOR pathway, Autophagy, RPTOR
References
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- Crosstalk Between Apoptosis and Autophagy : BH3 Mimetics Activate Multiple Pro-Autophagic Pathways
- Extending lifespan using various prolongevity interventions and their effects on enhancing dna repair activity
- Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells.
- An improved bioluminescence resonance energy transfer strategy for imaging intracellular events in single cells and living subjects.
- Autophagy in aging and in neurodegenerative disorders
- Association of aminoacyl-tRNA synthetases with cancer.
- Evaluation of rapamycin-induced cell death.
- The FKBP-rapamycin binding domain of human TOR undergoes strong conformational changes in the presence of membrane mimetics with and without the regulator phosphatidic acid.
- Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition
- Effect of folate deficiency on mTOR signaling network on the liver of wild type mice
- Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life.
- Papel de mTOR na formação e reconsolidação da memória
- The mammalian target of rapamycin kinase and tumor growth inhibition.
- Mammalian target of rapamycin: a central node of complex signaling cascades.
- Investigation into the molecular mechanisms of inherited renal cancer
- Intracellular kinases in semaphorin signaling.
- The role of inflammation in sarcoma.
- Physiological regulation of Akt activity and stability.
- Downregulation of mTOR by lentivirus inhibits prostate cancer cell growth.
- Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy
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