CSF-1R inhibition alters macrophage polarization and blocks glioma progression
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Summary
The results identify TAMs as a promising therapeutic target for proneural gliomas and establish the translational potential of CSF-1R inhibition for GBM.
- Type
- article
- Published
- 2013-09-22
- Cited by
- 2,229
- References
- 115
- Access
- Open access
- OpenAlex
- https://openalex.org/W1980485314
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9849614
Keywords
Glioma, Cancer research, Microglia, Biology, M2 Macrophage
References
- Factor XIIIa-immunoreactivity in tumors of the central nervous system.
- Liposomes for specific depletion of macrophages from organs and tissues.
- Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M.
- Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling
- Conditional Macrophage Ablation Demonstrates That Resident Macrophages Initiate Acute Peritoneal Inflammation1
- Biochemical Fractionation of Brain Tissue for Studies of Receptor Distribution and Trafficking
- Arginase-1 and Ym1 Are Markers for Murine, but Not Human, Alternatively Activated Myeloid Cells
- ggplot2: Elegant Graphics for Data Analysis
- Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1β System by IL-131
- Granulocyte-Macrophage Colony-Stimulating Factor (CSF) and Macrophage CSF-Dependent Macrophage Phenotypes Display Differences in Cytokine Profiles and Transcription Factor Activities: Implications for CSF Blockade in Inflammation1
- CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
- Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells
- Differential Macrophage Programming in the Tumor Microenvironment
- Modeling Adult Gliomas Using RCAS/t-va Technology.
- Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.
- Genetically Engineered Mouse Models of Brain Cancer and the Promise of Preclinical Testing
- Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers.
- Identification of factor XIII-A as a marker of alternative macrophage activation
- Genetic and Pharmacological Targeting of CSF-1/CSF-1R Inhibits Tumor-Associated Macrophages and Impairs BRAF-Induced Thyroid Cancer Progression
- ‘Green mice’ as a source of ubiquitous green cells
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- Endothelial cell‐derived angiopoietin‐2 is a therapeutic target in treatment‐naive and bevacizumab‐resistant glioblastoma
- Microglia–blood vessel interactions: a double-edged sword in brain pathologies
- Regulation of microglial survival and proliferation in health and diseases
- Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging
- Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas
- The emerging roles of macrophages in cancer metastasis and response to chemotherapy
- Novel concept of the border niche: glioblastoma cells use oligodendrocytes progenitor cells (GAOs) and microglia to acquire stem cell-like features
- Podoplanin Positive Myeloid Cells Promote Glioma Development by Immune Suppression
- Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy.
- Discovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages.
- Tumor-associated myeloid cells: diversity and therapeutic targeting
- Rôle pro-inflammatoire et immunomodulateur de la proteinase 3 membranaire exprimée au cours de l'apoptose : implications dans la granulomatose avec polyangéite
- Therapeutic strategies for targeting the ovarian tumor stroma.
- Characterizing and Targeting Bone Marrow-Derived Inflammatory Cells in Driving the Malignancy and Progression of Childhood Astrocytic Brain Tumors
- CSF-1/CSF-1R targeting agents in clinical development for cancer therapy.
- More than a scaffold: Stromal modulation of tumor immunity.
- ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis
- Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.
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