CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
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Summary
The mechanistic link between CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer and the origin of these macrophages is defined by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice.
- Type
- article
- Published
- 2011-06-08
- Cited by
- 2,693
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1963904011
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4379281
Keywords
Extravasation, CCL2, Metastasis, Chemokine, CCR2
References
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- Recruitment of γδ T lymphocytes to tumors
- CCL2/CCR2-dependent recruitment of functional antigen-presenting cells into tumors upon chemotherapy.
- Role of sirtuins in chronic obstructive pulmonary disease
- Human CD64-targeted non-viral siRNA delivery system for blood monocyte gene modulation
- How Schwann cells facilitate cancer progression in nerves
- Phagocyte—extracellular matrix crosstalk empowers tumor development and dissemination
- Surface-Modified Macrophages Facilitate Tracking of Breast Cancer-Immune Interactions
- Myeloid-derived suppressor cell accumulation in renal cell carcinoma is correlated with CCL2, IL-17 and IL-18 expression in blood and tumors.
- PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2.
- CCR2 chemokine receptors enhance growth and cell cycle progression of breast cancer cells through SRC and PKC activation
- The emerging roles of macrophages in cancer metastasis and response to chemotherapy
- SIRPα expression delineates subsets of intratumoral monocyte/macrophages with different functional and prognostic impact in follicular lymphoma
- Tumor-associated myeloid cells: diversity and therapeutic targeting
- Rôle pro-inflammatoire et immunomodulateur de la proteinase 3 membranaire exprimée au cours de l'apoptose : implications dans la granulomatose avec polyangéite
- The fine balance of chemokines during disease: trafficking, inflammation and homeostasis
- IKK/nuclear factor-kappaB and oncogenesis: roles in tumor-initiating cells and in the tumor microenvironment.
- Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages.
- A Proinflammatory Role for Eph Receptors after Spinal Cord Injury
- Regulation of cancer stem cell activities by tumor-associated macrophages.
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