On the nature of susceptibility to cancer. The presidential address
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Summary
Although all evidence points to a multifactorial, multistage process, the rate of somatic mutation appears to be the key determinant factor in susceptibility to cancer.
- Type
- article
- Published
- 1980-09-15
- Cited by
- 107
- References
- 79
- Access
- Open access
- OpenAlex
- https://openalex.org/W2021040121
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37157134
Keywords
Cancer, Medicine, Genetic predisposition, Population, Risk factor
References
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- Zur Frage der Entstehung maligner Tumoren
- Immune function in healthy relatives of patients with malignant disease.
- Mutation selection and the natural history of cancer
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- The Age Distribution of Cancer: Implications for Models of Carcinogenesis
- The effect of aging and interval between primary and secondary treatment in two-stage carcinogenesis on mouse skin.
- Regulation of the immune response to tumor antigens. III. Characterization of thymic suppressor factor(s) produced by tumor-bearing hosts.
- The Nude Mouse vs. The Hypothesis of Immunological Surveillance
- Aging Increases Susceptibility of Mouse Skin to DMBA Carcinogenesis Independent of General Immune Status
- Age-dependent excision repair of damaged thymine from γ-irradiated DNA by isolated nuclei from human fibroblasts
- Viral transformation of cells from persons at high risk of cancer.
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- The Use of the Enhanced Recovery After Surgery (ERAS) Protocol in Patients Undergoing Laparoscopic Surgery for Colorectal Cancer--A Comparative Analysis of Patients Aged above 80 and below 55.
- Etiology of Cancer in Man
- Biology of Renal Cell Carcinoma
- Cáncer de pulmón en la provincia de Zaragoza (1980-1985).
- The Assessment of Glioblastoma Tumorspheres Reveals Molecular Determinants of Proliferation and Therapeutic Response
- The role of the systemic inflammatory response, the JAK STAT pathway and the MAPK pathway in the prognosis of resectable pancreatic cancer
- Cancer de pulmon en pacientes menores de 40 años
- Tumor-suppressive pathways in pancreatic carcinoma.
- Short‐term outcome following elective laparoscopic colorectal cancer resection in octogenarians and nonagenarians
- Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of human cancer causation.
- Urate and ascorbate: their possible roles as antioxidants in determining longevity of mammalian species.
- Cancer in the elderly: the forgotten priority.
- Effect of age on intestinal regeneration in the rabbit.
- Experimental tumors and aging: local factors that may account for the observed age advantage in the B16 murine melanoma model.
- Cancer of the prostate and aging: An autopsy study in black men from Washington, DC, and selected African cities
- The landscape of cancer genes and mutational processes in breast cancer
- Molecular changes consistent with increased proliferation and invasion are common in rectal cancer
- Cancer and the aging process.
- Conceptual Foundations of Chemoprevention: A Critical Analysis
- Malignant Neoplasm in Kidney Transplantation
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