Akt (Protein Kinase B) Negatively Regulates SEK1 by Means of Protein Phosphorylation*
Explore this paper's citation graph
Summary
Results suggest that Akt suppresses stress-activated signaling by targeting SEK1, the protein serine-threonine kinase that mediates cell survival signaling initiated by various growth-promoting factors such as insulin.
- Type
- article
- Published
- 2002-01-25
- Cited by
- 165
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974140472
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27116410
Keywords
Protein kinase B, Phosphorylation, Protein kinase A, Kinase, Cell biology
References
- Cellular signaling: pivoting around PDK-1.
- Induction of c‐fos expression through JNK‐mediated TCF/Elk‐1 phosphorylation.
- Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
- Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
- High-efficiency transformation of mammalian cells by plasmid DNA.
- Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
- Mechanism of activation and function of protein kinase B.
- A non-enzymatic p21 protein inhibitor of stress-activated protein kinases
- Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
- Transcription factor ATF2 regulation by the JNK signal transduction pathway
- JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
- Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development.
- Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation*
- Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
- Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase*
- Akt negatively regulates the cJun N‐terminal kinase pathway in PC12 cells
- Regulation of cell death protease caspase-9 by phosphorylation.
- Akt Protein Kinase Inhibits Rac1-GTP Binding through Phosphorylation at Serine 71 of Rac1*
- Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
- PI3K: downstream AKTion blocks apoptosis.
Cited by
- Signaling Events in Amyloid β-Peptide-induced Neuronal Death and Insulin-like Growth Factor I Protection*
- Elevated Akt Phosphorylation as an Indicator of Renal Tubular Epithelial Cell Stress*
- From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling.
- Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease.
- Interleukin (IL) 1β Induction of IL-6 Is Mediated by a Novel Phosphatidylinositol 3-Kinase-dependent AKT/IκB Kinase α Pathway Targeting Activator Protein-1*
- Role of the CC Chemokine receptor 9/TECK interaction in apoptosis
- Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades
- Mechanisms of activation and regulation of the heat shock-sensitive signaling pathways.
- Depolarization-dependent pro-survival signaling in spiral ganglion neurons
- Glucocorticoid-mediated apoptosis resistance of solid tumors.
- Protéomique fonctionnelle de la signalisation de la kinase AKT dans le cancer du sein
- Liver-X-receptor-mediated expression of key genes in macrophages implicated in the control of cholesterol homeostasis and atherosclerosis
- Structure, regulation and function of PKB/AKT--a major therapeutic target.
- Neurotrophin-based strategies for neuroprotection
- Complex regulation of Forkhead Box O transcription factors
- JNK regulation of oncogenesis.
- The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review).
- Molecular aspects of the stress response : chaperones, membranes and networks
- Whatever Happened to the Epoxyeicosatrienoic Acid-Like Endothelium-Derived Hyperpolarizing Factor? The Identification of Novel Classes of Lipid Mediators and Their Role in Vascular Homeostasis
- Refolding of protein kinases
Related papers
- Photo-Activatable Akt Probe: A New Tool to Study the Akt-Dependent Physiopathology of Cancer Cells
- The Effect of O-GlcNAcylation on Phosphorylation of tau
- Regulation of neutrophil apoptosis by modulation of PKB/Akt activation.
- pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependentmanner
- Roles of mammalian sterile 20‐like kinase 2‐dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2‐related kinases
- c‐Myc transactivation domain‐associated kinases: Questionable role for map kinases in c‐Myc phosphorylation
- Supplemental Figure 6: UAB30 did not alter expression or phosphorylation of kinases. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies
- Supplemental Figure 6: UAB30 did not alter expression or phosphorylation of kinases. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies
- PSEA: Kinase-specific prediction and analysis of human phosphorylation substrates