PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
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Summary
The data indicate that the immunoregulatory PD-1/PD-L1 pathway is operative during a persistent viral infection in humans, and define a reversible defect in HIV-specific T-cell function.
- Type
- article
- Published
- 2006-09-21
- Cited by
- 2,857
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W1978436252
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3115462
Keywords
CD8, Cytotoxic T cell, T cell, Immunology, Viral load
References
- Loss of HIV-1–specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1–specific CD4+ T Cells
- The B7–CD28 superfamily
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- Skewed maturation of memory HIV-specific CD8 T lymphocytes
- Programmed Death-1 (PD-1) is a Marker of Germinal Center-associated T Cells and Angioimmunoblastic T-Cell Lymphoma
- Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
- HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
- Enhanced expression of CTLA‐4 (CD152) on CD4+ T cells in HIV infection
- Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
- Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA
- Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
- Phenotypic Analysis of Antigen-Specific T Lymphocytes
- Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity
- HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication.
- Restoring function in exhausted CD8 T cells during chronic viral infection
- Progress in Defining CD4 Helper Cell Responses in Chronic Viral Infections
- Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes
- A Significant Number of Human Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes Detected by Tetramer Binding Do Not Produce Gamma Interferon
- Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS.
- HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
Cited by
- Estudio del rol de la vía de PD-1 sobre la respuesta inmune de células Nk y de los mecanismos inmunológicos inducidos por las células Th9 frente a la infección por M. tuberculosis
- The biological and clinical significance of the maternal immune response to fetal antigens
- Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction
- Host and viral factors contributing to CD8+ T cell failure in hepatitis C virus infection.
- PD-1 Regulates Self-Reactive CD8+ T Cell Responses to Antigen in Lymph Nodes and Tissues1
- Aiming for successful vaccine-induced HIV-1-specific cytotoxic T lymphocytes
- B7‐H1 up‐regulation impairs myeloid DC and correlates with disease progression in chronic HIV‐1 infection
- PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV.
- Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C.
- Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways.
- The combination of 4‐1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV‐specific T cell responses
- EBV-Specific CD8+ T Cells from Asymptomatic Pediatric Thoracic Transplant Patients Carrying Chronic High EBV Loads Display Contrasting Features: Activated Phenotype and Exhausted Function
- Shelterin Dysfunction and p16INK4a-Mediated Growth Inhibition in HIV-1-Specific CD8 T Cells
- Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection
- SIV increases susceptibility to tuberculosis by manipulating M. tuberculosis-specific immunological responses
- Combination antiretroviral therapy with raltegravir leads to rapid immunologic reconstitution in treatment-naive patients with chronic HIV infection.
- HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-κB Pathway
- Chronic hepatitis B: a wave of new therapies on the horizon
- Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapy.
- CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients.
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