Skewed maturation of memory HIV-specific CD8 T lymphocytes
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Summary
A skewed maturation of HIV-specific memory CD8+ T cells during HIV infection is demonstrated through analysis of cell division, which demonstrates a two-step process characterized initially by a phase of proliferation largely restricted to the CCR7+CD8+ cell subsets, followed by aphase of functional maturation encompassing the C CR7-CD8- cell subset.
- Type
- article
- Published
- 2001-03-01
- Cited by
- 1,164
- References
- 29
- OpenAlex
- https://openalex.org/W1945834141
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4407897
Keywords
C-C chemokine receptor type 7, Cytotoxic T cell, CD8, Biology, Immunology
References
- HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.
- Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population.
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
- Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
- Effect of highly active antiretroviral therapy on outcomes in Veterans Affairs Medical Centers.
- Changing Virus‐Host Interactions in the Course of HIV‐1 Infection
- Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
- Immunology Taught by Viruses
- Lymphocyte Homing and Homeostasis
- Lifespan of human lymphocyte subsets defined by CD45 isoforms
- Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV
- Determination of lymphocyte division by flow cytometry.
- T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4+ T Cell Turnover
- Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo
- Phenotypic Analysis of Antigen-Specific T Lymphocytes
- Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.
- CD8+ T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity.
- Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.
- Induction of immunological paralysis in two zones of dosage
- HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
Cited by
- Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection.
- The fraction of perforin-expressing HIV-specific CD8 T cells is a marker for disease progression in HIV infection
- Ablation of CD8 and CD4 T Cell Responses by High Viral Loads1
- The chemokine receptor CX3CR1 controls homing and anti‐viral potencies of CD8 effector‐memory T lymphocytes in HIV‐infected patients
- Sometimes help may not be enough.
- HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity
- T-CELL AND NEURONAL APOPTOSIS IN HIV INFECTION: IMPLICATIONS FOR THERAPEUTIC INTERVENTION
- Qualitative T-Helper Responses to Multiple Viral Antigens Correlate with Vaccine-Induced Immunity to Simian/Human Immunodeficiency Virus Infection
- HIV‐1 Nef equips dendritic cells to reduce survival and function of CD8+ T cells: a mechanism of immune evasion
- Interleukin‐7 signalling is sufficient to phenotypically and functionally prime human CD4+ naïve T cells
- Human Immunodeficiency Virus Type 1 Controllers but Not Noncontrollers Maintain CD4 T Cells Coexpressing Three Cytokines
- Aiming for successful vaccine-induced HIV-1-specific cytotoxic T lymphocytes
- Immunologic features of HIV‐1‐infected women on HAART at delivery
- Poor Lymphoproliferative Responses with Low Proportion of Gag-Specific CD8 TEMRA Cells in HIV-1-Infected Patients Showing Immunological and Virological Discordance Despite Prolonged Suppression of Plasma Viremia
- Nef-specific CD45RA+ CD8+ T cells secreting MIP-1β but not IFN-γ are associated with nonprogressive HIV-1 infection
- Characterization of the Cellular and Molecular Factors Mediating Antigen-Independent Noncytolytic CD8+ T Cell Suppression of HIV-1
- SIV increases susceptibility to tuberculosis by manipulating M. tuberculosis-specific immunological responses
- Primary and recall cytotoxic T lymphocyte responses to autologous antigen in HIV-1-infected subjects
- CCR5 Antagonism Impacts Vaccination Response and Immune Profile in HIV-1 Infection
- Immune system modulation by helminth infections: potential impact on HIV transmission and disease progression.
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