Programmed Death-1 (PD-1) is a Marker of Germinal Center-associated T Cells and Angioimmunoblastic T-Cell Lymphoma
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Summary
PD-1 is a useful new marker for angioimmunoblastic lymphoma and lends further support to a model of T-cell lymphomagenesis in which specific sub types of T cells may undergo neoplastic transformation and result in specific, distinct histologic, immunophenotypic, and clinical subtypes ofT-cell neoplasia.
- Type
- article
- Published
- 2006-07-01
- Cited by
- 336
- References
- 21
- Access
- Open access
- OpenAlex
- https://openalex.org/W1985563120
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29676391
Keywords
Angioimmunoblastic T-cell lymphoma, Germinal center, Lymphoma, Pathology, Neoplastic transformation
References
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- Expression pattern of T-cell-associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma.
- The B7–CD28 superfamily
- CD10: A Review
- Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells.
- Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms.
- Microanatomical localization of PD-1 in human tonsils.
- Characteristic proliferations of reticular and dendritic cells in angioimmunoblastic lymphoma.
- T-bet, a T-cell-associated transcription factor, is expressed in a subset of B-cell lymphoproliferative disorders.
- Differential expression of T-bet, a T-box transcription factor required for Th1 T-cell development, in peripheral T-cell lymphomas.
- Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells.
- Loss of expression of the WNT/beta-catenin-signaling pathway transcription factors lymphoid enhancer factor-1 (LEF-1) and T cell factor-1 (TCF-1) in a subset of peripheral T cell lymphomas.
- Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4
- Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10.
- Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma.
- The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.
- T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells1
- Subspecialization of Cxcr5+ T Cells
- Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production 1
- Pathology and genetics: Tumours of haematopoietic and lymphoid tissues
Cited by
- Follicular programmed death 1-positive lymphocytes in the tumor microenvironment are an independent prognostic factor in follicular lymphoma.
- Sequential development of diffuse large B‐cell lymphoma in a patient with angioimmunoblastic T‐cell lymphoma
- Is CD10 Antibody Useful in the Diagnosis of Angioimmunoblastic T-Cell Lymphoma?
- T-cell lymphomas, a challenging disease: types, treatments, and future
- Pathology of T-cell lymphomas: diagnosis and biomarker discovery.
- ZUSAMMENSETZUNG DES BEGLEITINFILTRATS UND KOEXPRESSION VON B-ZELL-TRANSKRIPTIONSFAKTOREN IN FOLLIKULÄREN LYMPHOMEN
- Tfh cell differentiation and their function in promoting B-cell responses.
- Programmed death-1 (PD-1), programmed death-ligand 1 (PD-L1), and EBV-encoded RNA (EBER) expression in Hodgkin lymphoma
- Pathogenesis and targeted therapy of T-cell lymphoma
- Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma.
- T follicular helper cells during immunity and tolerance.
- Programmed death‐1 expression in cutaneous B‐cell lymphoma
- The B7 Homologues and their Receptors in Hematologic Malignancies
- Reactive T cells by flow cytometry distinguish Hodgkin lymphomas from T cell/histiocyte‐rich large B cell lymphoma
- High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new‐onset rheumatoid arthritis
- A case report of angioimmunoblastic T cell lymphoma (AITL) with localization of neoplastic clear cells in the outer zone of germinal centers
- From antibodies to diagnosis: FOXP3 and PD-1 markers of human lymphoid malignancies
- Angioimmunoblastic T-cell lymphoma: a tumor of follicular helper T cells derivation with clinical and pathological relevance
- Morphologische und funktionelle Untersuchungen zur Rolle des Transkriptionsfaktors T-bet in erregerbedingten Lymphknotenerkrankungen, Autoimmunerkrankungen und malignen Lymphomen
- Use of PD-1, CD1a, and S-100 in Differentiating Pseudolymphomatous Folliculitis and Indolent Primary Cutaneous B-Cell Lymphomas
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