Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes
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Summary
It is indicated that HIV-1-specific CTL can efficiently lyse HIV- 1-infected CD4+ cells and suggest that the partial downregulation of class I molecules in infected cells does not significantly affect recognition by CTL.
- Type
- article
- Published
- 1996-09-01
- Cited by
- 243
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2106628454
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23025096
Keywords
CTL*, Biology, Cytotoxic T cell, Virology, Epitope
References
- In vivo persistence of a HIV‐1‐encoded HLA‐B27‐restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity
- Adenovirus region E3 proteins that prevent cytolysis by cytotoxic T cells and tumor necrosis factor.
- Human retroviruses and AIDS 1996. A compilation and analysis of nucleic acid and amino acid sequences
- Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag.
- HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.
- Bi-specific monoclonal antibodies: selective binding and complement fixation to cells that express two different surface antigens.
- Mapping the fine specificity of a cytolytic T cell response to HIV-1 nef protein.
- Detection of major histocompatibility complex class I-restricted, HIV-specific cytotoxic T lymphocytes in the blood of infected hemophiliacs.
- Evaluation of human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T-lymphocyte responses utilizing B-lymphoblastoid cell lines transduced with the CD4 gene and infected with HIV-1
- Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.
- Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infection.
- Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
- Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
- Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.
- Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS
- Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
- Herpes simplex virus turns off the TAP to evade host immunity
- A viral inhibitor of peptide transporters for antigen presentation
- Why can't cytotoxic T cells handle HIV?
- Downregulation of HLA Class I Antigens in HIV-1-Infected Cells
Cited by
- Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms
- Aiming for successful vaccine-induced HIV-1-specific cytotoxic T lymphocytes
- Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones
- HIV Immune Evasion: Disruption of antigen presentation by the HIV Nef protein
- HIV-1 gene expression: characterization of viruses with altered transcription elements
- RELATIONSHIP BETWEEN SYSTEMIC AND CENTRAL NERVOUS SYSTEM MONOCYTE/MACROPHAGE INFECTION IN SIMIAN IMMUNODEFICIENCY VIRUS ENCEPHALITIS
- Immune control of HIV-1 replication.
- The Determinants of CD8+ Cytotoxic T Lymphocyte Antiviral Activity Against Human Immunodeficiency Virus Type 1
- A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion.
- Theoretische Untersuchungen zur MHC I Antigenpräsentation
- HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8+ CD28- T subset
- CTL quality and the control of human retroviral infections
- EFFECT OF COMBINATION EXPOSURE TO ZIDOVUDINE AND SULFAMETHOXAZOLE-TRIMETHOPRIM ON IMMUNE RESPONSE IN MICE AND HUMANS
- Modulation of HIV immune responses in natural infection and after genetic immunization
- Factores inmunitarios protectivos del huésped contra la infección por el VIH-1 y la progresión a SIDA: quimiocinas y sus receptores.
- MHC-I–restricted presentation of HIV-1 virion antigens without viral replication
- Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL 1
- Role of cellular immunity in protection against HIV infection.
- Mechanisms of HIV‐1 to escape from the host immune surveillance
- CD8+ cells in human immunodeficiency virus type I pathogenesis: cytolytic and noncytolytic inhibition of viral replication.
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