The mitochondrial pathways of apoptosis.
Explore this paper's citation graph
Summary
The current view on the mitochondrial pathway of apoptosis is presented with a particular attention to new aspects of the regulation of the Bcl-2 proteins family control of mitochondrial membrane permeabilization: the mechanisms implicated in their mitochondrial targeting and activation during apoptosis, the function(s) of the oncosuppressive protein p53 at the mitochondria and the role of the processes of mitochondrial fusion and fission.
- Type
- review
- Published
- 2012-01-01
- Cited by
- 297
- References
- 274
- Access
- Open access
- OpenAlex
- https://openalex.org/W116732461
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206763637
Keywords
Cell biology, Mitochondrion, Apoptosis, Programmed cell death, Caspase
References
- Genetic control of programmed cell death in the nematode C. elegans.
- Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300
- PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53
- Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology
- Bcl-2 initiates a new category of oncogenes: regulators of cell death.
- PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2
- Bcl‐2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.
- Parc: a cytoplasmic anchor for p53.
- The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast
- Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus.
- Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
- P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA.
- p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma.
- Flotillins and the PHB Domain Protein Family: Rafts, Worms and Anaesthetics
- Mitochondrial membrane permeabilization in cell death.
- The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.
- Bid, a BH3-only multi-functional molecule, is at the cross road of life and death.
- The prohibitin family of mitochondrial proteins regulate replicative lifespan.
- A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
- OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28
Cited by
- Baicalin protects human skin fibroblasts from ultraviolet A radiation-induced oxidative damage and apoptosis
- The regulatory T cell effector soluble fibrinogen-like protein 2 induces tubular epithelial cell apoptosis in renal transplantation
- Phosphatidylserine-mediated cellular signaling.
- Régulation de l’apoptose dépendante de p53 par le FGF1 intracellulaire : caractérisation des mécanismes d’action
- Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling.
- Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance
- Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
- Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid
- GYY4137, a hydrogen sulfide (H₂S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway.
- Spinocerebellar ataxia type 35 (SCA35)-associated transglutaminase 6 mutants sensitize cells to apoptosis.
- Flow cytometric characterization of apoptosis and chromatin damage in spermatozoa.
- Cell Based Assays: the Cell Cycle, Cell Proliferation and Cell Death
- Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells.
- Effects of atrazine on the proliferation and cytotoxicity of murine lymphocytes with the use of carboxyfluorescein succinimidyl ester-based flow cytometric approaches.
- Pleurotus eous polysaccharides suppress angiogenesis and induce apoptosis via ROS-dependent JNK activation and mitochondrial mediated mechanisms in MCF-7 human breast cancer cells
- Melatonin is involved in the apoptosis and necrosis of pancreatic cancer cell line SW-1990 via modulating of Bcl-2/Bax balance.
- Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity.
- Bile acids in the colon, from healthy to cytotoxic molecules.
- Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways.
- [Programmed cell death comes in many flavors].
Related papers
- Cell Stress-Associated Caspase Activation: Intrinsically Complex?
- Initiator caspases in apoptosis signaling pathways
- Apoptotic death sensor: an organelle's alter ego?
- Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation
- Regulation of the Drosophila Apoptosome through Feedback Inhibition
- Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases.
- Acute ammonia neurotoxicity in vivo involves the increase in cytoplasmic protein P53 without alterations in other markers of apoptosis
- The Apoptosome at High Resolution
- The apoptosome: physiological, developmental, and pathological modes of regulation.