Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology
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Summary
Overexpression of the pro-apoptotic protein appoptosin impairs interaction of the mitochondrial fusion proteins MFN1 and MFN2, and reduces mitochondrial fusion activity, leading to mitochondrial fragmentation.
- Type
- article
- Published
- 2016-03-01
- Cited by
- 31
- References
- 54
- OpenAlex
- https://openalex.org/W2333552486
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31541206
Keywords
Biology, mitochondrial fusion, Translocase of the inner membrane, Cell biology, Morphology (biology)
References
- Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations
- hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery*
- Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission–fusion proteins
- Activated Mitofusin 2 Signals Mitochondrial Fusion, Interferes with Bax Activation, and Reduces Susceptibility to Radical Induced Depolarization*[boxs]
- Mitochondrial dynamics--mitochondrial fission and fusion in human diseases.
- Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia
- Transcriptional regulation of APH‐1A and increased γ‐secretase cleavage of APP and Notch by HIF‐1 and hypoxia
- Structural Basis of Mitochondrial Tethering by Mitofusin Complexes
- Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution.
- Mitochondrial Fission, Fusion, and Stress
- Missense SLC25A38 variations play an important role in autosomal recessive inherited sideroblastic anemia
- High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy.
- Mitochondria-targeted antioxidants protect against Abeta toxicity in Alzheimer’s disease neurons
- Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis
- MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival
- Mitochondrial fusion and fission in cell life and death
- Mitochondrial carrier proteins
- Appoptosin is a Novel Proapoptotic Protein and Mediates Cell Death in Neurodegeneration
- Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
- Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1
Cited by
- Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals
- Mitochondrial-Shaping Proteins in Cardiac Health and Disease – the Long and the Short of It!
- Progressive supranuclear palsy.
- Regulation of Mitochondrial Dynamics by Proteolytic Processing and Protein Turnover
- Biological Implications of Differential Expression of Mitochondrial-Shaping Proteins in Parkinson’s Disease
- Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells
- Insights into the genotype-phenotype correlation and molecular function of SLC25A46
- The vicious circle between mitochondrial oxidative stress and dynamic abnormality mediates triethylene glycol dimethacrylate-induced preodontoblast apoptosis.
- Role of GTPases in the regulation of mitochondrial dynamics in Parkinson's disease.
- Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.
- Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway
- Divide et Impera: Drp1-mediated Mitochondrial Fission in Glioma Malignancy
- Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging
- Baicalein inhibits mitochondrial apoptosis induced by oxidative stress in cardiomyocytes by stabilizing MARCH5 expression
- A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis
- Smokeless tobacco induces toxicity and apoptosis in neuronal cells: a mechanistic evaluation
- Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases.
- Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer
- Management of Hypercholesterolemia Through Dietary ß-glucans–Insights From a Zebrafish Model
- Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation
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