Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen Presenting Cells, Critical for T cell Immunity
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Summary
Across multiple mouse tumor models and human tumor biopsies, the intratumoral dendritic-cell populations as distinct from macrophage populations are delineated, finding CD103+ DCs are extremely sparse and yet remarkably capable CTL stimulators.
- Type
- article
- Published
- 2014-10-16
- Cited by
- 779
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W1976199086
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206523590
Keywords
Cytotoxic T cell, CTL*, Biology, Immune system, Myeloid
References
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- CD301b+ dermal dendritic cells drive T helper-2 cell mediated immunity
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- Macrophages and therapeutic resistance in cancer
- Microenvironment: The new midfielders in the tumour microenvironment
- T cell exclusion, immune privilege, and the tumor microenvironment
- The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells?
- CD103+ dendritic cells producing interleukin-12 in anticancer immunosurveillance.
- Systems approaches to unravel innate immune cell diversity, environmental plasticity and functional specialization.
- Immune cell promotion of metastasis
- Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Dendritic Cells Induces Potent Antitumoral Responses
- Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines
- The Emerging Understanding of Myeloid Cells as Partners and Targets in Tumor Rejection
- Adaptive Immune Regulation of Mammary Postnatal Organogenesis
- Immune suppressive mechanisms in the tumor microenvironment
- Reprogramming the tumor microenvironment to enhance adoptive cellular therapy.
- Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells
- Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling.
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